Seroatlas · Human Serome Atlas

SYNPO2L

Synaptopodin 2-like protein

Also known as: FLJ12921, SYP2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H987
Gene: SYNPO2L
Ensembl: ENSG00000166317
Chromosome: 10
Canonical length: 977 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in Z disc; actin cytoskeleton; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

977 residues, UniProt reviewed canonical sequence.

>Q9H987|SYNPO2L
     1  MGAEEEVLVT LSGGAPWGFR LHGGAEQRKP LQVSKIRRRS QAGRAGLRER DQLLAINGVS
    61  CTNLSHASAM SLIDASGNQL VLTVQRLADE GPVQSPSPHE LQVLSPLSPL SPEPPGAPVP
   121  QPLQPGSLRS PPDSEAYYGE TDSDADGPAT QEKPRRPRRR GPTRPTPPGA PPDEVYLSDS
   181  PAEPAPTIPG PPSQGDSRVS SPSWEDGAAL QPPPAEALLL PHGPLRPGPH LIPMVGPVPH
   241  PVAEDLTTTY TQKAKQAKLQ RAESLQEKSI KEAKTKCRTI ASLLTAAPNP HSKGVLMFKK
   301  RRQRAKKYTL VSFGAAAGTG AEEEDGVPPT SESELDEEAF SDARSLTNQS DWDSPYLDME
   361  LARAGSRASE GQGSGLGGQL SEVSGRGVQL FEQQRQRADS STQELARVEP AAMLNGEGLQ
   421  SPPRAQSAPP EAAVLPPSPL PAPVASPRPF QPGGGAPTPA PSIFNRSARP FTPGLQGQRP
   481  TTTSVIFRPL APKRANDSLG GLSPAPPPFL SSQGPTPLPS FTSGVPSHAP VSGSPSTPRS
   541  SGPVTATSSL YIPAPSRPVT PGGAPEPPAP PSAAAMTSTA SIFLSAPLRP SARPEAPAPG
   601  PGAPEPPSAR EQRISVPAAR TGILQEARRR GTRKQMFRPG KEETKNSPNP ELLSLVQNLD
   661  EKPRAGGAES GPEEDALSLG AEACNFMQPV GARSYKTLPH VTPKTPPPMA PKTPPPMTPK
   721  TPPPVAPKPP SRGLLDGLVN GAASSAGIPE PPRLQGRGGE LFAKRQSRAD RYVVEGTPGP
   781  GLGPRPRSPS PTPSLPPSWK YSPNIRAPPP IAYNPLLSPF FPQAARTLPK AQSQGPRATP
   841  KQGIKALDFM RHQPYQLKTA MFCFDEVPPT PGPIASGSPK TARVQEIRRF STPAPQPTAE
   901  PLAPTVLAPR AATTLDEPIW RTELASAPVP SPAPPPEAPR GLGASPSSCG FQVARPRFSA
   961  TRTGLQAHVW RPGAGHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNPO2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 261 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 261 nTPM
heart muscle: 245 nTPM
tongue: 82 nTPM
esophagus: 11 nTPM
salivary gland: 4.4 nTPM
breast: 3.4 nTPM

Single-cell type

cardiomyocytes: 195 nCPM
thymic myoid cells: 184 nCPM
myonuclei: 91 nCPM
esophageal apical cells: 29 nCPM
epicardial cells: 21 nCPM
mesothelial cells: 7 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.4 nTPM
plasmacytoid DC: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 4.6 nTPM
hippocampal formation: 4.5 nTPM
amygdala: 4.4 nTPM
basal ganglia: 4.4 nTPM
cerebral cortex: 4.4 nTPM
cerebellum: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNPO2L as an antibody target. Whether an autoantibody or antibody against SYNPO2L could matter depends on whether native SYNPO2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNPO2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNPO2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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