Seroatlas · Human Serome Atlas

SYNGR3

Synaptogyrin-3

Also known as: SNG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43761
Gene: SYNGR3
Ensembl: ENSG00000127561
Chromosome: 16
Canonical length: 229 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>O43761|SYNGR3
     1  MEGASFGAGR AGAALDPVSF ARRPQTLLRV ASWVFSIAVF GPIVNEGYVN TDSGPELRCV
    61  FNGNAGACRF GVALGLGAFL ACAAFLLLDV RFQQISSVRD RRRAVLLDLG FSGLWSFLWF
   121  VGFCFLTNQW QRTAPGPATT QAGDAARAAI AFSFFSILSW VALTVKALQR FRLGTDMSLF
   181  ATEQLSTGAS QAYPGYPVGS GVEGTETYQS PPFTETLDTS PKGYQVPAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNGR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 125 nTPM
cerebral cortex: 115 nTPM
cerebellum: 79 nTPM
midbrain: 75 nTPM
amygdala: 64 nTPM
basal ganglia: 50 nTPM

Single-cell type

other brain neurons: 64 nCPM
brain inhibitory neurons: 41 nCPM
oocytes: 37 nCPM
brain excitatory neurons: 29 nCPM
undifferentiated spermatogonia: 13 nCPM
retinal ganglion cells: 12 nCPM

Immune cell

naive B-cell: 1.8 nTPM
NK-cell: 1.8 nTPM
memory B-cell: 1 nTPM
memory CD8 T-cell: 0.9 nTPM
naive CD4 T-cell: 0.7 nTPM
MAIT T-cell: 0.6 nTPM

Brain region

pons: 247 nTPM
thalamus: 242 nTPM
hypothalamus: 222 nTPM
cerebral cortex: 193 nTPM
midbrain: 188 nTPM
basal ganglia: 158 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.53
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH2 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNGR3 as an antibody target. Whether an autoantibody or antibody against SYNGR3 could matter depends on whether native SYNGR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNGR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNGR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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