Seroatlas · Human Serome Atlas

SYNC

Syncoilin

Also known as: SYNC1, SYNCI_HUMAN, SYNCOILIN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H7C4
Gene
SYNC
Ensembl
ENSG00000162520
Chromosome
1
Canonical length
482 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q9H7C4|SYNC
     1  MASPEPRRGG DGAAQAARKT RVEANSPLPK NSGSLNEAEA LNPEVTLSSE GSLNLEDILY
    61  LEDTGDLDET LYVQETEKAE EALYIEEAMQ PDEALHVEEP GNPEETVCVE ETTEPDRIQF
   121  VEGPVEPGKP TSPEHVVYEG ETVTRAEKSN PEESLRAEQS PSMEENLSIE DLELLEGRFQ
   181  QCVQAVAQLE EERDQLIHEL VLLREPALQE VQQVHQDILA AYKLHAQAEL ERDGLREEIR
   241  LVKQKLFKVT KECVAYQYQL ECRQQDVAQF ADFREVLTTR ATQLSEELAQ LRDAYQKQKE
   301  QLRQQLEAPP SQRDGHFLQE SRRLSAQFEN LMAESRQDLE EEYEPQFLRL LERKEAGTKA
   361  LQRTQAEIQE MKEALRPLQA EARQLRLQNR NLEDQIALVR QKRDEEVQQY REQLEEMEER
   421  QRQLRNGVQL QQQKNKEMEQ LRLSLAEELS TYKAMLLPKS LEQADAPTSQ AGGMETQSQG
   481  AV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 100 nTPM
  • tongue: 69 nTPM
  • smooth muscle: 50 nTPM
  • blood vessel: 27 nTPM
  • esophagus: 17 nTPM
  • heart muscle: 16 nTPM

Single-cell type

  • thymic myoid cells: 158 nCPM
  • myonuclei: 146 nCPM
  • peritubular myoid cells: 85 nCPM
  • sertoli cells: 65 nCPM
  • differentiating spermatogonia: 64 nCPM
  • leydig cells: 63 nCPM

Immune cell

  • plasmacytoid DC: 12 nTPM
  • total PBMC: 12 nTPM
  • myeloid DC: 9.7 nTPM
  • intermediate monocyte: 9.6 nTPM
  • non-classical monocyte: 9.6 nTPM
  • NK-cell: 9.2 nTPM

Brain region

  • spinal cord: 17 nTPM
  • midbrain: 16 nTPM
  • medulla oblongata: 15 nTPM
  • white matter: 14 nTPM
  • hypothalamus: 14 nTPM
  • thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.67
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • intermediate filament-based process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYNC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNC as an antibody target. Whether an autoantibody or antibody against SYNC could matter depends on whether native SYNC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYNC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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