Seroatlas · Human Serome Atlas

SYCP2L

Synaptonemal complex protein 2-like

Also known as: C6orf177, dJ62D2.1, NO145, SYC2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T4T6
Gene: SYCP2L
Ensembl: ENSG00000153157
Chromosome: 6
Canonical length: 812 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to act upstream of or within negative regulation of programmed cell death. Located in condensed chromosome, centromeric region and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

812 residues, UniProt reviewed canonical sequence.

>Q5T4T6|SYCP2L
     1  MQAKNKDALQ PIKEDRTGKA QDDAFWLQSL ITDAFHDKGF QKIKEYFQQK ESHFPQKYNR
    61  LLLYRLDRSI NKELDKNEFQ SVSLLLKCIQ RFLVDGLKED EPLLIRQGLI PKLVSWFERT
   121  TGILTSEGLA SDTSLICVIE DFFDTALIIS RSSSEGKIQM LDSFLLSLGF LVTEKTVNHL
   181  LQQEGLKTFN CILHAVPREE RKKFPLSEGM CHLMKDLART LLTVGDYDQQ VAISEALCRL
   241  TIKKSRDELV HKWFDDEVIA EAFKEIKDRE FETDSRRFLN HLNNRLGDQR RVYSFPCIAA
   301  FADEHEMRKP ADEKLEKFWI DFNLGSQSVT FYIDNAENTL WDSVTLPKEA VMNFSITETE
   361  KIKIFIIYLK KPMIISYKEV MKIEIHFDLQ FNISQVSIQA LGEDKQMLPD QTKISSELFS
   421  KSDKEDRESP SGLERETEQA EESTNMVEFM SAEDDRCLIT LHLNDQSEPP VIGEPASDSH
   481  LQPVPPFGVP DFPQQPKSHY RKHLFSESNQ DSSTSELSWT SNQKKKSLKS YSSRKKTRTR
   541  SNLRILPVFP PSSGSGHEKD QAKLLSPSEK EIPEQNNTTS PKTSEQKFQD SFAFLTAEDS
   601  AQKTELQDPH SLSELSSLKH SEDEEKPKIV NQESLTESTS LKHKLRNLED KDIPEGSFAK
   661  SQQSRLEEEV APGSPFSITE ERELPEGIST SSLEVVPENL NGSAILPTFE NFTKKRKRKY
   721  ELRYRKRPFN SENAKKAPDC LIKLLNQMQL FRLNKLERFQ NLVLQELSSL KQDIQALEHL
   781  EKEVLEFWGK QSADLQSFCD LQVLRFNSTQ TS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYCP2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 65 nTPM
testis: 3 nTPM
epididymis: 2.4 nTPM
lung: 1.7 nTPM
pancreas: 1.7 nTPM
cerebellum: 1.4 nTPM

Single-cell type

epicardial cells: 130 nCPM
oocytes: 92 nCPM
mast cells: 60 nCPM
pdcs: 54 nCPM
undifferentiated spermatogonia: 30 nCPM
late primary spermatocytes: 29 nCPM

Immune cell

plasmacytoid DC: 4.2 nTPM
eosinophil: 3.4 nTPM
basophil: 1.7 nTPM
myeloid DC: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 5.4 nTPM
white matter: 5 nTPM
cerebellum: 4.3 nTPM
amygdala: 3.8 nTPM
basal ganglia: 3.6 nTPM
hippocampal formation: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYCP2L.

Disease | AllUniProt

Conditions SYCP2L is implicated in, by any mechanism.

Premature ovarian failure 24 (POF24) MIM:620840

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Premature ovarian failure 24
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of programmed cell death

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYCP2L as an antibody target. Whether an autoantibody or antibody against SYCP2L could matter depends on whether native SYCP2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYCP2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYCP2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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