Seroatlas · Human Serome Atlas

SWT1

Transcriptional protein SWT1

Also known as: C1orf26, FLJ20121, HsSwt1, SWT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T5J6
Gene: SWT1
Ensembl: ENSG00000116668
Chromosome: 1
Canonical length: 900 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

900 residues, UniProt reviewed canonical sequence.

>Q5T5J6|SWT1
     1  MSSKESCGKK ETSQRKDTTT SSPNFGEKDK KERKTPASST SSSSIRSVSS EKRKLKSDHT
    61  DVLYYNIKRR QGLKRLSVEI DTLRRRPKIG SSSQRPIKLK EASYSNDNQI ILQSPSSNGT
   121  KKDIHKCVDF KPKDIKLTNA GSKLDHGIKS LSSPKIASDV KPKAEGQASE NKWSHLLVQR
   181  EKMKELKKGR NSKFRDNSEK CVLEKWKRNQ FSQDYNSNKI IKEPLGSRRQ KISFKIPIKS
   241  RDTLQKLVEE NVFNIDSNNS KTKQEEREYL ESSQVSLNVT RQKTEHLLSD FTYKRTVHEW
   301  KRKHHYDHQE SNDSHSRENL TQSFEAPCCS VSSESIQDAD QEMQIVEELH AARVGKSVDL
   361  PGELMSMEID LEDDVHSSSA NNTSDRKLLI VIDTNILMNH LKFVRILKTT EVPGFDKLVL
   421  IIPWVVMQEL DRMKEGKLLK RAQHKAIPAV HFINDSLKNQ DRKLWGQSIQ LASQKHYGLS
   481  DENNDDRVLK CCLQHQELFP CSFVILCTDD RNLRNKGLIS GVKSLSKEEL SAELLHLSLN
   541  TDVCHQPCIP KQQLKAETTP LKESYKEEST NSGLSILLES IVSDLEKSLG TGLSSILETE
   601  MKIAFGNLWM EILYLKPPWT LLHLLQCFKK HWLAVFGLVM EKNLLLTIES LYKNLRKANK
   661  AVDFTTVKFL LQDSRSLLHA FSTRSNYDGI LPQTFAQVNN LLQTFAEVKT KLKPNSSENT
   721  VTKKQEGTSL KNSHNQEITV FSSSHLPQPS RHQEIWSILE SVWITIYQNS TDVFQRLGSN
   781  SALTTSNIAS FEEAFICLQK LMAAVRDILE GIQRILAPNS NYQDVETLYN FLIKYEVNKN
   841  VKFTAQEIYD CVSQTEYREK LTIGCRQLVE MEYTMQQCNA SVYMEAKNRG WCEDMLNYRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SWT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

testis: 36 nTPM
pancreas: 8.7 nTPM
bone marrow: 8.5 nTPM
salivary gland: 6.1 nTPM
ovary: 5.7 nTPM
placenta: 5.2 nTPM

Single-cell type

late primary spermatocytes: 240 nCPM
early spermatids: 163 nCPM
neutrophils: 153 nCPM
adrenal medulla cells: 128 nCPM
epicardial cells: 111 nCPM
bergmann glia: 98 nCPM

Immune cell

basophil: 14 nTPM
T-reg: 6.2 nTPM
neutrophil: 5.6 nTPM
non-classical monocyte: 4.3 nTPM
naive B-cell: 3.3 nTPM
memory CD4 T-cell: 3.1 nTPM

Brain region

white matter: 17 nTPM
basal ganglia: 15 nTPM
hypothalamus: 14 nTPM
medulla oblongata: 14 nTPM
midbrain: 14 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 1.49
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

PIN domain
PIN-like domain superfamily
PIN domain
SWT1 Transcriptional Regulator

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SWT1 as an antibody target. Whether an autoantibody or antibody against SWT1 could matter depends on whether native SWT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SWT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SWT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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