Seroatlas · Human Serome Atlas

SWAP70

Switch-associated protein 70

Also known as: KIAA0640, SWAP-70, SWP70_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UH65
Gene
SWAP70
Ensembl
ENSG00000133789
Chromosome
11
Canonical length
585 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments

OverviewNCBI Gene

Enables cadherin binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. Is active in postsynapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q9UH65|SWAP70
     1  MGSLKEELLK AIWHAFTALD QDHSGKVSKS QLKVLSHNLC TVLKVPHDPV ALEEHFRDDD
    61  EGPVSNQGYM PYLNRFILEK VQDNFDKIEF NRMCWTLCVK KNLTKNPLLI TEEDAFKIWV
   121  IFNFLSEDKY PLIIVSEEIE YLLKKLTEAM GGGWQQEQFE HYKINFDDSK NGLSAWELIE
   181  LIGNGQFSKG MDRQTVSMAI NEVFNELILD VLKQGYMMKK GHRRKNWTER WFVLKPNIIS
   241  YYVSEDLKDK KGDILLDENC CVESLPDKDG KKCLFLVKCF DKTFEISASD KKKKQEWIQA
   301  IHSTIHLLKL GSPPPHKEAR QRRKELRKKQ LAEQEELERQ MKELQAANES KQQELEAVRK
   361  KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR
   421  ELEDMYLKLQ EALEDERQAR QDEETVRKLQ ARLLEEESSK RAELEKWHLE QQQAIQTTEA
   481  EKQELENQRV LKEQALQEAM EQLEQLELER KQALEQYEEV KKKLEMATNK TKSWKDKVAH
   541  HEGLIRLIEP GSKNPHLITN WGPAAFTEAE LEEREKNWKE KKTTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SWAP70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 71 nTPM
  • lymph node: 62 nTPM
  • spleen: 56 nTPM
  • adipose tissue: 37 nTPM
  • placenta: 37 nTPM
  • appendix: 35 nTPM

Single-cell type

  • b-cells: 424 nCPM
  • vascular endothelial cells: 322 nCPM
  • extravillous trophoblasts: 275 nCPM
  • syncytiotrophoblasts: 254 nCPM
  • endometrial ciliated cells: 243 nCPM
  • microglia: 229 nCPM

Immune cell

  • naive B-cell: 85 nTPM
  • memory B-cell: 81 nTPM
  • eosinophil: 49 nTPM
  • non-classical monocyte: 30 nTPM
  • basophil: 20 nTPM
  • intermediate monocyte: 14 nTPM

Brain region

  • choroid plexus: 28 nTPM
  • medulla oblongata: 28 nTPM
  • spinal cord: 27 nTPM
  • white matter: 26 nTPM
  • pons: 25 nTPM
  • thalamus: 23 nTPM

ReferencesPubMed · IEDB

Publications for SWAP70 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.05
gnomAD missense Z
1.83
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SWAP70 as an antibody target. Whether an autoantibody or antibody against SWAP70 could matter depends on whether native SWAP70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SWAP70 is annotated at the cell surface, where native SWAP70 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SWAP70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SWAP70. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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