Seroatlas · Human Serome Atlas

SVIP

Small VCP/p97-interacting protein

Also known as: DKFZp313A2432, SVIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHG7
Gene
SVIP
Ensembl
ENSG00000198168
Chromosome
11
Canonical length
77 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

77 residues, UniProt reviewed canonical sequence.

>Q8NHG7|SVIP
     1  MGLCFPCPGE SAPPTPDLEE KRAKLAEAAE RRQKEAASRG ILDVQSVQEK RKKKEKIEKQ
    61  IATSGPPPEG GLRWTVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SVIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 28 nTPM
  • thyroid gland: 22 nTPM
  • stomach: 18 nTPM
  • epididymis: 17 nTPM
  • bone marrow: 17 nTPM
  • hypothalamus: 16 nTPM

Single-cell type

  • early spermatids: 1,014 nCPM
  • platelets: 911 nCPM
  • late primary spermatocytes: 752 nCPM
  • parietal cells: 453 nCPM
  • oocytes: 387 nCPM
  • late spermatids: 386 nCPM

Immune cell

  • plasmacytoid DC: 24 nTPM
  • eosinophil: 23 nTPM
  • naive CD4 T-cell: 16 nTPM
  • memory CD4 T-cell: 13 nTPM
  • memory B-cell: 13 nTPM
  • naive B-cell: 13 nTPM

Brain region

  • white matter: 31 nTPM
  • spinal cord: 27 nTPM
  • medulla oblongata: 24 nTPM
  • hypothalamus: 24 nTPM
  • thalamus: 24 nTPM
  • pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small VCP/p97-interacting protein
  • Small VCP/p97-interacting protein, metazoa
  • Small VCP/p97-interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SVIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SVIP as an antibody target. Whether an autoantibody or antibody against SVIP could matter depends on whether native SVIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SVIP is annotated at the cell surface, where native SVIP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SVIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SVIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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