Seroatlas · Human Serome Atlas

SUPT20HL2

Transcription factor SPT20 homolog-like 2

Also known as: FAM48B2, SP202_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7V6
Gene: SUPT20HL2
Ensembl: ENSG00000223611
Chromosome: X
Canonical length: 817 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

817 residues, UniProt reviewed canonical sequence.

>P0C7V6|SUPT20HL2
     1  MDRDLEQALD RTENITEIAQ QRRPRRRYSP RAGKTLQEKL YDIYVEECGK EPEDPQELRS
    61  NVNLLEKLVR RESLPCLLVN LYPGNQGYSV MLQREDGSFA ETIRLPYEER ALLDYLDAEE
   121  LPPALGDVLD KASVNIFHSG CVIVEVRDYR QSSNMQPPGY QSRHILLRPT MQTLAPEVKT
   181  MTRDGEKWSQ EDKFPLESQL ILATAEPLCL DPSVAVACTA NRLLYNKQKM NTDPMEQCLQ
   241  RYSWPSVKPQ QEQSDCPPPP ELRVSTSGQK EERKVGQPCE LNITKAGSCV DTWKGRPCDL
   301  AVPSEVDVEK LAKGYQSVTA ADPQLPVWPA QEVEDPFRHA WEAGCQAWDT KPNIMQSFND
   361  PLLCGKIRPR KKARQKSQKS PWQPFPDDHS ACLRPGSETD AGRAVSQAQE SVQSKVKGPG
   421  KMSHSSSGPA SVSQLSSWKT PEQPDPVWVQ SSVSGKGEKH PPPRTQLPSS SGKISSGNSF
   481  PPQQAGSPLK RPFPAAAPAV AAAAPAPAPA PAAAPALAAA AVAAAAGGAA PSHSQKPSVP
   541  LIKASRRRPA AGRPTRFVKI APAIQVRTGS TGLKATNVEG PVRGAQVLGC SFKPVQAPGS
   601  GAPAPAGISG SGLQSSGGPL PDARPGAVQA SSPAPLQFFL NTPEGLRPLT LQVPQGWAVL
   661  TGPQQQSHQL VSLQQLQQPT AAHPPQPGPQ GSTLGLSTQG QAFPAQQLLN VNLTGAGSGL
   721  QPQPQAAVLS LLGSAQVPQQ GVQLPFVLGQ QPQPLLLLQP QPQPQQIQLQ TQPLRVLQQP
   781  VFLATGAVQI VQPHPGVQAG SQLVGQRKGG KPTPPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT20HL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1.8 nTPM
testis: 1.5 nTPM
fallopian tube: 0.7 nTPM
epididymis: 0.6 nTPM
retina: 0.6 nTPM
bone marrow: 0.4 nTPM

Single-cell type

early primary spermatocytes: 23 nCPM
differentiating spermatogonia: 7.9 nCPM
oocytes: 4.6 nCPM
undifferentiated spermatogonia: 4.3 nCPM
sertoli cells: 2.8 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 1.6 nTPM
neutrophil: 0.8 nTPM
non-classical monocyte: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
eosinophil: 0.3 nTPM

Brain region

white matter: 9.3 nTPM
cerebral cortex: 8.2 nTPM
amygdala: 7.1 nTPM
hippocampal formation: 6.7 nTPM
pons: 6.5 nTPM
thalamus: 6.5 nTPM

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

transcription coregulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT20HL2 as an antibody target. Whether an autoantibody or antibody against SUPT20HL2 could matter depends on whether native SUPT20HL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT20HL2 is annotated as secreted, so native SUPT20HL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SUPT20HL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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