Seroatlas · Human Serome Atlas

SUPT20HL1

Transcription factor SPT20 homolog-like 1

Also known as: SP201_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3ZLR7
Gene: SUPT20HL1
Canonical length: 823 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SUPT20HL1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>Q3ZLR7|SUPT20HL1
     1  MDRDLEQALD RAENIIEIAQ QRPPRRRYSP RAGKTLQEKL YDIYVEECGK EPEDPQELRS
    61  NVNLLEKLVR RESLPCLLVN LYPGNQGYSV MLQREDGSFA ETIRLPYEER ALLDYLDAEE
   121  LPPALGDVLD KASVNIFHSG CVIVEVRDYR QSSNMQPPGY QSRHILLRPT MQTLAHDVKM
   181  MTRDGQKWSQ EDKLQLESQL ILATAEPLCL DPSVAVACTA NRLLYNKQKM NTDPMKRCLQ
   241  RYSWPSVKPQ QEQSDCPPPP ELRVSTSGQK EERKVGQPCE LNIAKAGSCV DTWKGRPCDL
   301  AVPSEVDVEK LAKGYQSVTA ADPQLPVWPA QEVEDPFGFA LEAGCQAWDT KPSIMQSFND
   361  PLLCGKIRPR KKARQKSQKS PWQPFPDDHS ACLRPGSETD AGRAVSQAQE SVQSKVKGPG
   421  KMSHSSSGPA SVSQLSSWKT PEQPDPVWVQ SSVSGKGEKH PPPRTQLPSS SGKISSGNSF
   481  PPQQAGSPLK PAAPAAAASA APSHSQKPSV PLIQASRPCP AAQPPTKFIK IAPAIQLRTG
   541  STGLKAINVE GPVQGAQALG SSFKPVQAPG SGAPAPAGIS GSDLQSSGGP LPDARPGAVQ
   601  ASSPAPLQFF LNTPEGLRPL TLLQVPQGSA VLTGPQQQSH QLVSLQQLQQ PTAAHPPQPG
   661  PQGSALGLST QGQAFPAQQL LKVNPTRARS GLQPQPQPAV LSLLGSAQVP QQGVQLPSVL
   721  RQQQPQPQPP KLQLQPQWQP KPRQEQPQSQ QQQPQHIQLQ TQQLRVLQQP QHIQLQTQQL
   781  RVLQQPVFLA TGAVQIVQPH PGVQVGSQLV DQRKEGKPTP PAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT20HL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

testis: 0.4 nTPM
endometrium: 0.1 nTPM
heart muscle: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

early primary spermatocytes: 6.4 nCPM
fibro-adipogenic progenitors: 1.5 nCPM
peritubular myoid cells: 1.4 nCPM
leydig cells: 1.2 nCPM
schwann cells: 0.9 nCPM
fibroblasts: 0.5 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 0.6 nTPM
cerebellum: 0.5 nTPM
midbrain: 0.5 nTPM
medulla oblongata: 0.4 nTPM
pons: 0.4 nTPM
spinal cord: 0.4 nTPM

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT20HL1 as an antibody target. Whether an autoantibody or antibody against SUPT20HL1 could matter depends on whether native SUPT20HL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT20HL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUPT20HL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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