Seroatlas · Human Serome Atlas

SUGP2

SURP and G-patch domain-containing protein 2

Also known as: KIAA0365, SFRS14, SUGP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IX01
Gene: SUGP2
Ensembl: ENSG00000064607
Chromosome: 19
Canonical length: 1082 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

1082 residues, UniProt reviewed canonical sequence.

>Q8IX01|SUGP2
     1  MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR AEMYDDVHSD
    61  GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD SYFRKECGRD LEFSHSDSRD
   121  QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE
   181  KECLEKESRD YDVDHPGEAD SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG
   241  VGKLVTLRNV STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL
   301  GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL FQTLFELETE
   361  TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG AVKTKNCFFE
   421  IIKPFDKYIM RLQDRLLKSV TPLLMACNAY ELSVKMKTLS NPLDLALALE TTNSLCRKSL
   481  ALLGQTFSLA SSFRQEKILE AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC
   541  PLQVKKAEPE PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG
   601  SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK PTSADCAVRA
   661  MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT QTLLSSGTRL KHHGRQAPGL
   721  SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS LEASGPSPKP AGVDISEAPQ TSSPCPSADI
   781  DMKTMETAEK LARFVAQVGP EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS
   841  ICFTSSPHNL HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE
   901  DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR KRISSKSLKV
   961  GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK DLDFAQQKLT DKNLGFQMLQ
  1021  KMGWKEGHGL GSLGKGIREP VSVGTPSEGE GLGADGQEHK EDTFDVFRQR MMQMYRHKRA
  1081  NK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUGP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 96 nTPM
testis: 83 nTPM
thyroid gland: 58 nTPM
cerebral cortex: 57 nTPM
pituitary gland: 52 nTPM
basal ganglia: 47 nTPM

Single-cell type

early primary spermatocytes: 237 nCPM
late primary spermatocytes: 204 nCPM
late spermatids: 196 nCPM
brain inhibitory neurons: 132 nCPM
lactotrophs: 127 nCPM
brain excitatory neurons: 124 nCPM

Immune cell

NK-cell: 4.4 nTPM
basophil: 4 nTPM
gdT-cell: 2 nTPM
plasmacytoid DC: 2 nTPM
naive B-cell: 1.7 nTPM
intermediate monocyte: 1.5 nTPM

Brain region

cerebral cortex: 89 nTPM
hippocampal formation: 83 nTPM
cerebellum: 74 nTPM
white matter: 72 nTPM
amygdala: 71 nTPM
choroid plexus: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUGP2 as an antibody target. Whether an autoantibody or antibody against SUGP2 could matter depends on whether native SUGP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUGP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUGP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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