Seroatlas · Human Serome Atlas

SUGCT

Succinyl-CoA:glutarate CoA-transferase

Also known as: C7orf10, DERP13, FLJ11808, ORF19, SUCHY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAC7
Gene: SUGCT
Ensembl: ENSG00000175600
Chromosome: 7
Canonical length: 438 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Microtubules,Mitotic spindle,Primary cilium,Basal body

OverviewNCBI Gene

This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q9HAC7|SUGCT
     1  MLATLARVAA LRRTCLFSGR GGGRGLWTGR PQSDMNNIKP LEGVKILDLT RVLAGPFATM
    61  NLGDLGAEVI KVERPGAGDD TRTWGPPFVG TESTYYLSVN RNKKSIAVNI KDPKGVKIIK
   121  ELAAVCDVFV ENYVPGKLSA MGLGYEDIDE IAPHIIYCSI TGYGQTGPIS QRAGYDAVAS
   181  AVSGLMHITG PENGDPVRPG VAMTDLATGL YAYGAIMAGL IQKYKTGKGL FIDCNLLSSQ
   241  VACLSHIAAN YLIGQKEAKR WGTAHGSIVP YQAFKTKDGY IVVGAGNNQQ FATVCKILDL
   301  PELIDNSKYK TNHLRVHNRK ELIKILSERF EEELTSKWLY LFEGSGVPYG PINNMKNVFA
   361  EPQVLHNGLV MEMEHPTVGK ISVPGPAVRY SKFKMSEARP PPLLGQHTTH ILKEVLRYDD
   421  RAIGELLSAG VVDQHETH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUGCT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

kidney: 41 nTPM
liver: 27 nTPM
choroid plexus: 10 nTPM
skeletal muscle: 9.7 nTPM
adrenal gland: 8.6 nTPM
blood vessel: 8.2 nTPM

Single-cell type

proximal tubule cells: 911 nCPM
adrenal cortex cells: 270 nCPM
myonuclei: 261 nCPM
choroid plexus epithelial cells: 249 nCPM
ependymal cells: 246 nCPM
fibro-adipogenic progenitors: 197 nCPM

Immune cell

naive CD4 T-cell: 1.4 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD4 T-cell: 0.7 nTPM
memory B-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

choroid plexus: 8.9 nTPM
midbrain: 4.1 nTPM
medulla oblongata: 3.9 nTPM
hypothalamus: 3.7 nTPM
spinal cord: 3.5 nTPM
thalamus: 3.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SUGCT.

Disease | AllUniProt

Conditions SUGCT is implicated in, by any mechanism.

Glutaric aciduria 3 (GA3) MIM:231690

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 193 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Glutaryl-CoA oxidase deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

succinate-hydroxymethylglutarate CoA-transferase activity

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

CoA-transferase family III
CoA-transferase family III domain 1 superfamily
CoA-transferase family III domain 3 superfamily
CoA-transferase family III
CoA-transferase III domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUGCT as an antibody target. Whether an autoantibody or antibody against SUGCT could matter depends on whether native SUGCT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUGCT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUGCT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...