Seroatlas · Human Serome Atlas

SUCNR1

Succinate receptor 1

Also known as: GPR91, SUCR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXA5
Gene: SUCNR1
Ensembl: ENSG00000198829
Chromosome: 3
Canonical length: 334 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q9BXA5|SUCNR1
     1  MLGIMAWNAT CKNWLAAEAA LEKYYLSIFY GIEFVVGVLG NTIVVYGYIF SLKNWNSSNI
    61  YLFNLSVSDL AFLCTLPMLI RSYANGNWIY GDVLCISNRY VLHANLYTSI LFLTFISIDR
   121  YLIIKYPFRE HLLQKKEFAI LISLAIWVLV TLELLPILPL INPVITDNGT TCNDFASSGD
   181  PNYNLIYSMC LTLLGFLIPL FVMCFFYYKI ALFLKQRNRQ VATALPLEKP LNLVIMAVVI
   241  FSVLFTPYHV MRNVRIASRL GSWKQYQCTQ VVINSFYIVT RPLAFLNSVI NPVFYFLLGD
   301  HFRDMLMNQL RHNFKSLTSF SRWAHELLLS FREK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUCNR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

kidney: 37 nTPM
thyroid gland: 8.8 nTPM
bone marrow: 7.6 nTPM
stomach: 7.4 nTPM
spleen: 6.6 nTPM
liver: 4.9 nTPM

Single-cell type

kupffer cells: 121 nCPM
platelets: 95 nCPM
neutrophil progenitors: 75 nCPM
microglia: 34 nCPM
hofbauer cells: 33 nCPM
macrophages: 29 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
eosinophil: 0.4 nTPM
non-classical monocyte: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

thalamus: 1.1 nTPM
medulla oblongata: 0.7 nTPM
pons: 0.6 nTPM
hypothalamus: 0.5 nTPM
white matter: 0.5 nTPM
midbrain: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: 0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUCNR1 as an antibody target. Whether an autoantibody or antibody against SUCNR1 could matter depends on whether native SUCNR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUCNR1 is annotated at the cell surface, where native SUCNR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SUCNR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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