Seroatlas · Human Serome Atlas

STYXL2

Serine/threonine/tyrosine-interacting-like protein 2

Also known as: DUSP27, STYL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZP5
Gene: STYXL2
Ensembl: ENSG00000198842
Chromosome: 1
Canonical length: 1158 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be located in sarcomere. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1158 residues, UniProt reviewed canonical sequence.

>Q5VZP5|STYXL2
     1  MATRKDTEEE QVVPSEEDEA NVRAVQAHYL RSPSPSQYSM VSDAETESIF MEPIHLSSAI
    61  AAKQIINEEL KPPGVRADAE CPGMLESAEQ LLVEDLYNRV REKMDDTSLY NTPCVLDLQR
   121  ALVQDRQEAP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT
   181  GLEIQYLGVE VDDFPEVDIS QHFRKASEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL
   241  MIFHNMAILE ALMTVRKKRA IYPNEGFLKQ LRELNEKLME EREEDYGREG GSAEAEEGEG
   301  TGSMLGARVH ALTVEEEDDS ASHLSGSSLG KATQASKPLT LIDEEEEEKL YEQWKKGQGL
   361  LSDKVPQDGG GWRSASSGQG GEELEDEDVE RIIQEWQSRN ERYQAEGYRR WGREEEKEEE
   421  SDAGSSVGRR RRTLSESSAW ESVSSHDIWV LKQQLELNRP DHGRRRRADS MSSESTWDAW
   481  NERLLEIEKE ASRRYHAKSK REEAADRSSE AGSRVREDDE DSVGSEASSF YNFCSRNKDK
   541  LTALERWKIK RIQFGFHKKD LGAGDSSGEP GAEEAVGEKN PSDVSLTAYQ AWKLKHQKKV
   601  GSENKEEVVE LSKGEDSALA KKRQRRLELL ERSRQTLEES QSMASWEADS STASGSIPLS
   661  AFWSADPSVS ADGDTTSVLS TQSHRSHLSQ AASNIAGCST SNPTTPLPNL PVGPGDTISI
   721  ASIQNWIANV VSETLAQKQN EMLLLSRSPS VASMKAVPAA SCLGDDQVSM LSGHSSSSLG
   781  GCLLPQSQAR PSSDMQSVLS CNTTLSSPAE SCRSKVRGTS KPIFSLFADN VDLKELGRKE
   841  KEMQMELREK MSEYKMEKLA SDNKRSSLFK KKKVKEDEDD GVGDGDEDTD SAIGSFRYSS
   901  RSNSQKPETD TCSSLAVCDH YASGSRVGKE MDSSINKWLS GLRTEEKPPF QSDWSGSSRG
   961  KYTRSSLLRE TESKSSSYKF SKSQSEEQDT SSYHEANGNS VRSTSRFSSS STREGREMHK
  1021  FSRSTYNETS SSREESPEPY FFRRTPESSE REESPEPQRP NWARSRDWED VEESSKSDFS
  1081  EFGAKRKFTQ SFMRSEEEGE KERTENREEG RFASGRRSQY RRSTDREEEE EMDDEAIIAA
  1141  WRRRQEETRT KLQKRRED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STYXL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 107 nTPM
heart muscle: 60 nTPM
tongue: 51 nTPM
blood vessel: 5.4 nTPM
placenta: 1.7 nTPM
prostate: 1.6 nTPM

Single-cell type

myonuclei: 262 nCPM
thymic myoid cells: 175 nCPM
cardiomyocytes: 59 nCPM
hofbauer cells: 47 nCPM
microglia: 14 nCPM
myosatellite cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1 nTPM
thalamus: 0.8 nTPM
choroid plexus: 0.6 nTPM
white matter: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of MAPK cascade

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STYXL2 as an antibody target. Whether an autoantibody or antibody against STYXL2 could matter depends on whether native STYXL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STYXL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STYXL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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