Seroatlas · Human Serome Atlas

STUM

Protein stum homolog

Also known as: C1orf95, DKFZp761P211, STUM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q69YW2
Gene
STUM
Ensembl
ENSG00000203685
Chromosome
1
Canonical length
141 aa
Protein class
Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>Q69YW2|STUM
     1  MEPSHKDAET AAAAAAVAAA DPRGASSSSG VVVQVREKKG PLRAAIPYMP FPVAVICLFL
    61  NTFVPGLGTF VSAFTVLCGA RTDLPDRHVC CVFWLNIAAA LIQILTAIVM VGWIMSIFWG
   121  MDMVILAISQ GYKEQGIPQQ L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STUM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 48 nTPM
  • cerebral cortex: 41 nTPM
  • hippocampal formation: 38 nTPM
  • basal ganglia: 22 nTPM
  • colon: 15 nTPM
  • hypothalamus: 11 nTPM

Single-cell type

  • thyrotrophs: 104 nCPM
  • lactotrophs: 93 nCPM
  • myosatellite cells: 92 nCPM
  • renal collecting duct intercalated cells: 88 nCPM
  • astrocytes: 67 nCPM
  • distal convoluted tubule cells: 45 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 551 nTPM
  • pons: 264 nTPM
  • cerebral cortex: 233 nTPM
  • thalamus: 136 nTPM
  • amygdala: 124 nTPM
  • hippocampal formation: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • SPEC3/Stum
  • Ectodermal ciliogenesis protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STUM as an antibody target. Whether an autoantibody or antibody against STUM could matter depends on whether native STUM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STUM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STUM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STUM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...