STRIT1
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
Also known as: DWORF, DWORF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DN84
- Gene
- STRIT1
- Ensembl
- ENSG00000240045
- Chromosome
- 3
- Canonical length
- 35 aa
- Protein class
- Predicted membrane proteins, Transporters
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Predicted to enable enzyme activator activity. Predicted to be involved in regulation of calcium ion transport and regulation of striated muscle contraction. Predicted to act upstream of or within positive regulation of ATPase-coupled calcium transmembrane transporter activity and positive regulation of calcium ion import. Predicted to be located in sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
35 residues, UniProt reviewed canonical sequence.
>P0DN84|STRIT1
1 MAEKAGSTFS HLLVPILLLI GWIVGCIIMI YVVFSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STRIT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 1,863 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 1,863 nTPM
- tongue: 652 nTPM
- basal ganglia: 36 nTPM
- esophagus: 13 nTPM
- prostate: 11 nTPM
- salivary gland: 10 nTPM
Single-cell type
- thymic myoid cells: 318 nCPM
- myonuclei: 104 nCPM
- proximal tubule cells: 22 nCPM
- respiratory ionocytes: 18 nCPM
- tuft cells: 12 nCPM
- myosatellite cells: 10 nCPM
Immune cell
- basophil: 0.8 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 33 nTPM
- thalamus: 17 nTPM
- white matter: 10 nTPM
- midbrain: 9.5 nTPM
- pons: 9.5 nTPM
- cerebellum: 8.3 nTPM
OntologyGO
Biological processes
- positive regulation of calcium ion import
- positive regulation of calcium ion import into sarcoplasmic reticulum
- positive regulation of cardiac muscle cell contraction
- regulation of ATPase-coupled calcium transmembrane transporter activity
- regulation of slow-twitch skeletal muscle fiber contraction
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
- Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STRIT1 as an antibody target. Whether an autoantibody or antibody against STRIT1 could matter depends on whether native STRIT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STRIT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label STRIT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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