Seroatlas · Human Serome Atlas

STOX1

Storkhead-box protein 1

Also known as: C10orf24, FLJ25162, STOX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZVD7
Gene
STOX1
Ensembl
ENSG00000165730
Chromosome
10
Canonical length
989 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to nitrosative stress; positive regulation of mitotic cell cycle phase transition; and regulation of macromolecule metabolic process. Located in centrosome; cytosol; and nuclear lumen. Implicated in pre-eclampsia. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

989 residues, UniProt reviewed canonical sequence.

>Q6ZVD7|STOX1
     1  MARPVQLAPG SLALVLCRLE AQKAAGAAEE PGGRAVFRAF RRANARCFWN ARLARAASRL
    61  AFQGWLRRGV LLVRAPPACL QVLRDAWRRR ALRPPRGFRI RAVGDVFPVQ MNPITQSQFV
   121  PLGEVLCCAI SDMNTAQIVV TQESLLERLM KHYPGIAIPS EDILYTTLGT LIKERKIYHT
   181  GEGYFIVTPQ TYFITNTTTQ ENKRMLPSDE SRLMPASMTY LVSMESCAES AQENAAPISH
   241  CQSCQCFRDM HTQDVQEAPV AAEVTRKSHR GLGESVSWVQ NGAVSVSAEH HICESTKPLP
   301  YTRDKEKGKK FGFSLLWRSL SRKEKPKTEH SSFSAQFPPE EWPVRDEDDL DNIPRDVEHE
   361  IIKRINPILT VDNLIKHTVL MQKYEEQKKY NSQGTSTDML TIGHKYPSKE GVKKRQGLSA
   421  KPQGQGHSRR DRHKARNQGS EFQPGSIRLE KHPKLPATQP IPRIKSPNEM VGQKPLGEIT
   481  TVLGSHLIYK KRISNPFQGL SHRGSTISKG HKIQKTSDLK PSQTGPKEKP FQKPRSLDSS
   541  RIFDGKAKEP YAEQPNDKME AESIYINDPT VKPINDDFRG HLFSHPQQSM LQNDGKCCPF
   601  MESMLRYEVY GGENEVIPEV LRKSHSHFDK LGETKQTPHS LPSRGASFSD RTPSACRLVD
   661  NTIHQFQNLG LLDYPVGVNP LRQAARQDKD SEELLRKGFV QDAETTSLEN EQLSNDDQAL
   721  YQNEVEDDDG ACSSLYLEED DISENDDLRQ MLPGHSQYSF TGGSQGNHLG KQKVIERSLT
   781  EYNSTMERVE SQVLKRNECY KPTGLHATPG ESQEPNLSAE SCGLNSGAQF GFNYEEEPSV
   841  AKCVQASAPA DERIFDYYSA RKASFEAEVI QDTIGDTGKK PASWSQSPQN QEMRKHFPQK
   901  FQLFNTSHMP VLAQDVQYEH SHLEGTENHS MAGDSGIDSP RTQSLGSNNS VILDGLKRRQ
   961  NFLQNVEGTK SSQPLTSNSL LPLTPVINV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 29 nTPM
  • cerebral cortex: 27 nTPM
  • choroid plexus: 26 nTPM
  • basal ganglia: 22 nTPM
  • midbrain: 18 nTPM
  • hippocampal formation: 16 nTPM

Single-cell type

  • choroid plexus epithelial cells: 308 nCPM
  • respiratory ciliated cells: 187 nCPM
  • astrocytes: 155 nCPM
  • pituitary stem cells: 155 nCPM
  • fallopian tube ciliated cells: 138 nCPM
  • endometrial ciliated cells: 115 nCPM

Immune cell

  • plasmacytoid DC: 1 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • choroid plexus: 40 nTPM
  • thalamus: 30 nTPM
  • cerebral cortex: 30 nTPM
  • amygdala: 30 nTPM
  • midbrain: 27 nTPM
  • hypothalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STOX1.

Disease | AllUniProt

Conditions STOX1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STOX1 as an antibody target. Whether an autoantibody or antibody against STOX1 could matter depends on whether native STOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STOX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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