STOML3
Stomatin-like protein 3
Also known as: Epb7.2l, SRO, STML3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TAV4
- Gene
- STOML3
- Ensembl
- ENSG00000133115
- Chromosome
- 13
- Canonical length
- 291 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Plasma membrane
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to act upstream of or within signal transduction. Predicted to be located in cilium; membrane raft; and neuron projection. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
291 residues, UniProt reviewed canonical sequence.
>Q8TAV4|STOML3
1 MDSRVSSPEK QDKENFVGVN NKRLGVCGWI LFSLSFLLVI ITFPISIWMC LKIIKEYERA
61 VVFRLGRIQA DKAKGPGLIL VLPCIDVFVK VDLRTVTCNI PPQEILTRDS VTTQVDGVVY
121 YRIYSAVSAV ANVNDVHQAT FLLAQTTLRN VLGTQTLSQI LAGREEIAHS IQTLLDDATE
181 LWGIRVARVE IKDVRIPVQL QRSMAAEAEA TREARAKVLA AEGEMNASKS LKSASMVLAE
241 SPIALQLRYL QTLSTVATEK NSTIVFPLPM NILEGIGGVS YDNHKKLPNK ALocalizationUniProt · AlphaFold · HPA
Whether an antibody against STOML3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 33 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 33 nTPM
- hippocampal formation: 2.8 nTPM
- hypothalamus: 2.3 nTPM
- basal ganglia: 2.2 nTPM
- lung: 1.9 nTPM
- choroid plexus: 1.7 nTPM
Single-cell type
- fallopian tube ciliated cells: 197 nCPM
- respiratory ciliated cells: 154 nCPM
- epididymal efferent duct ciliated cells: 110 nCPM
- endometrial ciliated cells: 100 nCPM
- ependymal cells: 80 nCPM
- extravillous trophoblasts: 17 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 11 nTPM
- medulla oblongata: 10 nTPM
- pons: 4.6 nTPM
- spinal cord: 4.4 nTPM
- hypothalamus: 3.7 nTPM
- choroid plexus: 2.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.73
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.37
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of STOML3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STOML3 as an antibody target. Whether an autoantibody or antibody against STOML3 could matter depends on whether native STOML3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STOML3 is annotated at the cell surface, where native STOML3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label STOML3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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