Seroatlas · Human Serome Atlas

STMND1

Stathmin domain-containing protein 1

Also known as: FLJ23152, STMD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BQB6
Gene
STMND1
Ensembl
ENSG00000230873
Chromosome
6
Canonical length
276 aa
Protein class
Predicted intracellular proteins
Subcellular location
Actin filaments

OverviewNCBI Gene

Predicted to be involved in regulation of microtubule polymerization or depolymerization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>H3BQB6|STMND1
     1  MGCGPSQPAE DRRRVRAPKK GWKEEFKADV SVPHTGENCS PRMEAALTKN TVDIAEGLEQ
    61  VQMGSLPGTI SENSPSPSER NRRVNSDLVT NGLINKPQSL ESRERQKSSD ILEELIVQGI
   121  IQSHSKVFRN GESYDVTLTT TEKPLRKPPS RLKKLKIKKQ VKDFTMKDIE EKMEAAEERR
   181  KTKEEEIRKR LRSDRLLPSA NHSDSAELDG AEVAFAKGLQ RVRSAGFEPS DLQGGKPLKR
   241  KKSKCDATLI DRNESDESFG VVESDMSYNQ ADDIVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STMND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 17 nTPM
  • choroid plexus: 7.7 nTPM
  • testis: 5 nTPM
  • gallbladder: 4.9 nTPM
  • breast: 2.8 nTPM
  • pancreas: 2.8 nTPM

Single-cell type

  • respiratory ciliated cells: 316 nCPM
  • fallopian tube ciliated cells: 161 nCPM
  • endometrial ciliated cells: 144 nCPM
  • epididymal efferent duct ciliated cells: 99 nCPM
  • respiratory deuterosomal cells: 57 nCPM
  • sertoli cells: 51 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • choroid plexus: 6 nTPM
  • white matter: 2 nTPM
  • medulla oblongata: 1.9 nTPM
  • midbrain: 1.8 nTPM
  • spinal cord: 1.8 nTPM
  • cerebellum: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
0
DepMap dependency class
none

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STMND1 as an antibody target. Whether an autoantibody or antibody against STMND1 could matter depends on whether native STMND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STMND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STMND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STMND1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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