Seroatlas · Human Serome Atlas

STMN4

Stathmin-4

Also known as: RB3, STMN4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H169
Gene: STMN4
Ensembl: ENSG00000015592
Chromosome: 8
Canonical length: 189 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable tubulin binding activity. Predicted to be involved in microtubule depolymerization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in Golgi apparatus and growth cone. Predicted to be active in cytoplasm and neuron projection. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q9H169|STMN4
     1  MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS
    61  GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR
   121  EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN
   181  KELKEEASR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STMN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 426 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 426 nTPM
cerebral cortex: 194 nTPM
hippocampal formation: 192 nTPM
midbrain: 186 nTPM
amygdala: 152 nTPM
hypothalamus: 142 nTPM

Single-cell type

oligodendrocytes: 235 nCPM
retinal horizontal cells: 66 nCPM
oligodendrocyte progenitor cells: 53 nCPM
retinal amacrine cells: 48 nCPM
other brain neurons: 42 nCPM
brain excitatory neurons: 41 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 415 nTPM
medulla oblongata: 267 nTPM
cerebral cortex: 257 nTPM
pons: 238 nTPM
cerebellum: 200 nTPM
hypothalamus: 194 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.09
gnomAD missense Z: 1.4
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STMN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAPK8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STMN4 as an antibody target. Whether an autoantibody or antibody against STMN4 could matter depends on whether native STMN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STMN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STMN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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