Seroatlas · Human Serome Atlas

STMN1

Stathmin

Also known as: C1orf215, FLJ32206, Lag, LAP18, OP18, PP17, PP19, PR22, SMN, STMN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P16949
Gene: STMN1
Ensembl: ENSG00000117632
Chromosome: 1
Canonical length: 149 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>P16949|STMN1
     1  MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER
    61  RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL
   121  ERLREKDKHI EEVRKNKESK DPADETEAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STMN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 1,367 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 1,367 nTPM
thymus: 1,250 nTPM
cerebral cortex: 1,038 nTPM
midbrain: 712 nTPM
hypothalamus: 705 nTPM
amygdala: 697 nTPM

Single-cell type

late spermatids: 3,457 nCPM
early spermatids: 1,053 nCPM
granulosa cells: 978 nCPM
late primary spermatocytes: 944 nCPM
hofbauer cells: 864 nCPM
extravillous trophoblasts: 692 nCPM

Immune cell

plasmacytoid DC: 425 nTPM
T-reg: 144 nTPM
naive CD4 T-cell: 78 nTPM
naive CD8 T-cell: 72 nTPM
memory CD8 T-cell: 68 nTPM
total PBMC: 57 nTPM

Brain region

white matter: 989 nTPM
cerebral cortex: 586 nTPM
hypothalamus: 570 nTPM
medulla oblongata: 546 nTPM
basal ganglia: 543 nTPM
pons: 530 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.08
gnomAD missense Z: 1.61
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STMN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KIST

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STMN1 as an antibody target. Whether an autoantibody or antibody against STMN1 could matter depends on whether native STMN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STMN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STMN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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