Seroatlas · Human Serome Atlas

STKLD1

Serine/threonine kinase-like domain-containing protein STKLD1

Also known as: C9orf96, MGC43306, SGK071, STKL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NE28
Gene: STKLD1
Ensembl: ENSG00000198870
Chromosome: 9
Canonical length: 680 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

680 residues, UniProt reviewed canonical sequence.

>Q8NE28|STKLD1
     1  MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET KVKHVIKQVE
    61  CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS SLYLCLVMEF NELSFQEVIE
   121  DKRKAKKIID SEWMQNVLGQ VLDALEYLHH LDIIHRNLKP SNIILISSDH CKLQDLSSNV
   181  LMTDKAKWNI RAEEDPFRKS WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH
   241  LRKSLRQSPG SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS
   301  FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK RLLKMPADQL
   361  GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA LVHHPEAKAP CNQAITSTLL
   421  SALQSHPEEE PLLVMVYSLL AITTTQESES LSEELQNAGL LEHILEHLNS SLESRDVCAS
   481  GLGLLWALLL DGIIVNKAPL EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ
   541  QFEQVVALLL QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET
   601  YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS LVSDSSAFSK
   661  PGLPPGGSPQ LGCTTSGGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STKLD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

testis: 9.4 nTPM
cerebellum: 0.6 nTPM
cerebral cortex: 0.5 nTPM
spinal cord: 0.5 nTPM
basal ganglia: 0.4 nTPM
hippocampal formation: 0.4 nTPM

Single-cell type

late spermatids: 66 nCPM
late primary spermatocytes: 15 nCPM
early spermatids: 15 nCPM
oligodendrocytes: 5.7 nCPM
astrocytes: 4.4 nCPM
brain excitatory neurons: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.4 nTPM
cerebral cortex: 2.3 nTPM
white matter: 2.2 nTPM
basal ganglia: 2 nTPM
amygdala: 1.8 nTPM
pons: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STKLD1 as an antibody target. Whether an autoantibody or antibody against STKLD1 could matter depends on whether native STKLD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STKLD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STKLD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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