STK32C
Serine/threonine-protein kinase 32C
Also known as: MGC23665, PKE, ST32C_HUMAN, YANK3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86UX6
- Gene
- STK32C
- Ensembl
- ENSG00000165752
- Chromosome
- 10
- Canonical length
- 486 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Canonical amino-acid sequenceUniProt
486 residues, UniProt reviewed canonical sequence.
>Q86UX6|STK32C
1 MRSGAERRGS SAAASPGSPP PGRARPAGSD APSALPPPAA GQPRARDSGD VRSQPRPLFQ
61 WSKWKKRMGS SMSAATARRP VFDDKEDVNF DHFQILRAIG KGSFGKVCIV QKRDTEKMYA
121 MKYMNKQQCI ERDEVRNVFR ELEILQEIEH VFLVNLWYSF QDEEDMFMVV DLLLGGDLRY
181 HLQQNVQFSE DTVRLYICEM ALALDYLRGQ HIIHRDVKPD NILLDERGHA HLTDFNIATI
241 IKDGERATAL AGTKPYMAPE IFHSFVNGGT GYSFEVDWWS VGVMAYELLR GWRPYDIHSS
301 NAVESLVQLF STVSVQYVPT WSKEMVALLR KLLTVNPEHR LSSLQDVQAA PALAGVLWDH
361 LSEKRVEPGF VPNKGRLHCD PTFELEEMIL ESRPLHKKKK RLAKNKSRDN SRDSSQSEND
421 YLQDCLDAIQ QDFVIFNREK LKRSQDLPRE PLPAPESRDA AEPVEDEAER SALPMCGPIC
481 PSAGSGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STK32C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 52 nTPM
Expression across tissuesHPA
Tissue
- testis: 52 nTPM
- cerebral cortex: 46 nTPM
- amygdala: 39 nTPM
- basal ganglia: 38 nTPM
- hippocampal formation: 31 nTPM
- hypothalamus: 22 nTPM
Single-cell type
- early spermatids: 305 nCPM
- late primary spermatocytes: 253 nCPM
- epididymal principal cells: 98 nCPM
- late spermatids: 88 nCPM
- mast cells: 55 nCPM
- cdc: 38 nCPM
Immune cell
- basophil: 56 nTPM
- myeloid DC: 25 nTPM
- intermediate monocyte: 20 nTPM
- classical monocyte: 18 nTPM
- non-classical monocyte: 17 nTPM
- eosinophil: 17 nTPM
Brain region
- cerebral cortex: 69 nTPM
- amygdala: 52 nTPM
- thalamus: 51 nTPM
- hippocampal formation: 51 nTPM
- basal ganglia: 49 nTPM
- midbrain: 42 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.49
- gnomAD pLI
- 0.2
- gnomAD missense Z
- 2.11
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STK32C as an antibody target. Whether an autoantibody or antibody against STK32C could matter depends on whether native STK32C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STK32C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label STK32C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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