STK32B
Serine/threonine-protein kinase 32B
Also known as: HSA250839, ST32B_HUMAN, STK32, STKG6, YANK2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NY57
- Gene
- STK32B
- Ensembl
- ENSG00000152953
- Chromosome
- 4
- Canonical length
- 414 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies,Cytosol
OverviewNCBI Gene
This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Canonical amino-acid sequenceUniProt
414 residues, UniProt reviewed canonical sequence.
>Q9NY57|STK32B
1 MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGSFGKVCIV QKRDTKKMYA MKYMNKQKCI
61 ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVHFTE
121 GTVKLYICEL ALALEYLQRY HIIHRDIKPD NILLDEHGHV HITDFNIATV VKGAERASSM
181 AGTKPYMAPE VFQVYMDRGP GYSYPVDWWS LGITAYELLR GWRPYEIHSV TPIDEILNMF
241 KVERVHYSST WCKGMVALLR KLLTKDPESR VSSLHDIQSV PYLADMNWDA VFKKALMPGF
301 VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKNRSRDG TKDSCPLNGH LQHCLETVRE
361 EFIIFNREKL RRQQGQGSQL LDTDSRGGGQ AQSKLQDGCN NNLLTHTCTR GCSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STK32B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- thymus: 18 nTPM
- kidney: 14 nTPM
- stomach: 5.7 nTPM
- hypothalamus: 4.2 nTPM
- testis: 4.2 nTPM
- breast: 4 nTPM
Single-cell type
- loop of henle epithelial cells: 299 nCPM
- oligodendrocyte progenitor cells: 294 nCPM
- lymphatic endothelial cells: 272 nCPM
- distal convoluted tubule cells: 272 nCPM
- early spermatids: 244 nCPM
- fibro-adipogenic progenitors: 204 nCPM
Immune cell
- plasmacytoid DC: 0.8 nTPM
- naive B-cell: 0.3 nTPM
- classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 15 nTPM
- hypothalamus: 8.2 nTPM
- midbrain: 7.5 nTPM
- medulla oblongata: 6.8 nTPM
- pons: 6.6 nTPM
- spinal cord: 6.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.98
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STK32B as an antibody target. Whether an autoantibody or antibody against STK32B could matter depends on whether native STK32B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STK32B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label STK32B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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