STK32A
Serine/threonine-protein kinase 32A
Also known as: MGC22688, ST32A_HUMAN, YANK1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WU08
- Gene
- STK32A
- Ensembl
- ENSG00000169302
- Chromosome
- 5
- Canonical length
- 396 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Centrosome
OverviewNCBI Gene
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
396 residues, UniProt reviewed canonical sequence.
>Q8WU08|STK32A
1 MGANTSRKPP VFDENEDVNF DHFEILRAIG KGSFGKVCIV QKNDTKKMYA MKYMNKQKCV
61 ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVHFKE
121 ETVKLFICEL VMALDYLQNQ RIIHRDMKPD NILLDEHGHV HITDFNIAAM LPRETQITTM
181 AGTKPYMAPE MFSSRKGAGY SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVHTFET
241 TVVTYPSAWS QEMVSLLKKL LEPNPDQRFS QLSDVQNFPY MNDINWDAVF QKRLIPGFIP
301 NKGRLNCDPT FELEEMILES KPLHKKKKRL AKKEKDMRKC DSSQTCLLQE HLDSVQKEFI
361 IFNREKVNRD FNKRQPNLAL EQTKDPQGED GQNNNLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STK32A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- midbrain: 11 nTPM
- adrenal gland: 11 nTPM
- hypothalamus: 9.6 nTPM
- thyroid gland: 8.1 nTPM
- cerebellum: 5.6 nTPM
- pituitary gland: 5.2 nTPM
Single-cell type
- bergmann glia: 845 nCPM
- pituicytes/fscs: 474 nCPM
- oligodendrocyte progenitor cells: 468 nCPM
- ependymal cells: 161 nCPM
- schwann cells: 119 nCPM
- astrocytes: 119 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 53 nTPM
- pons: 36 nTPM
- hypothalamus: 30 nTPM
- medulla oblongata: 30 nTPM
- cerebellum: 28 nTPM
- thalamus: 24 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.58
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STK32A as an antibody target. Whether an autoantibody or antibody against STK32A could matter depends on whether native STK32A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STK32A is annotated at the cell surface, where native STK32A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label STK32A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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