Seroatlas · Human Serome Atlas

STK17B

Serine/threonine-protein kinase 17B

Also known as: DRAK2, ST17B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94768
Gene: STK17B
Ensembl: ENSG00000081320
Chromosome: 2
Canonical length: 372 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in Flemming body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>O94768|STK17B
     1  MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA
    61  AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS
   121  LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF
   181  GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN
   241  QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN
   301  LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL
   361  PNPHELVSDL LC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK17B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 356 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 356 nTPM
lymph node: 106 nTPM
tonsil: 104 nTPM
appendix: 63 nTPM
thymus: 57 nTPM
spleen: 54 nTPM

Single-cell type

neutrophils: 3,217 nCPM
neutrophil progenitors: 1,112 nCPM
t-cells: 869 nCPM
mast cells: 790 nCPM
monocytes: 784 nCPM
cdc: 762 nCPM

Immune cell

neutrophil: 238 nTPM
basophil: 166 nTPM
eosinophil: 163 nTPM
non-classical monocyte: 113 nTPM
naive CD4 T-cell: 99 nTPM
total PBMC: 89 nTPM

Brain region

cerebral cortex: 16 nTPM
thalamus: 14 nTPM
hippocampal formation: 14 nTPM
cerebellum: 13 nTPM
choroid plexus: 12 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.01
gnomAD missense Z: 1.58
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Protein kinase domain
Serine/threonine-protein kinase 17B, catalytic domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK17B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CHP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK17B as an antibody target. Whether an autoantibody or antibody against STK17B could matter depends on whether native STK17B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK17B is annotated at the cell surface, where native STK17B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STK17B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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