Seroatlas · Human Serome Atlas

STK17A

Serine/threonine-protein kinase 17A

Also known as: DRAK1, ST17A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UEE5
Gene: STK17A
Ensembl: ENSG00000164543
Chromosome: 7
Canonical length: 414 aa
Protein class: Enzymes, Plasma proteins, Predicted membrane proteins
Subcellular location: Nuclear speckles,Plasma membrane

OverviewNCBI Gene

This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q9UEE5|STK17A
     1  MIPLEKPGSG GSSPGATSGS GRAGRGLSGP CRPPPPPQAR GLLTEIRAVV RTEPFQDGYS
    61  LCPGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD CRMEIIHEIA VLELAQDNPW
   121  VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTR
   181  DVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI
   241  SMATDMWSIG VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAVDFIRT
   301  LLVKKPEDRA TAEECLKHPW LTQSSIQEPS FRMEKALEEA NALQEGHSVP EINSDTDKSE
   361  TKESIVTEEL IVVTSYTLGQ CRQSEKEKME QKAISKRFKF EEPLLQEIPG EFIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK17A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

lymph node: 14 nTPM
tonsil: 13 nTPM
thymus: 8.4 nTPM
appendix: 7.5 nTPM
blood vessel: 7.5 nTPM
spleen: 6.9 nTPM

Single-cell type

neutrophils: 531 nCPM
t-cells: 479 nCPM
nk-cells: 460 nCPM
b-cells: 458 nCPM
alveolar cells type 1: 390 nCPM
pancreatic duct cells: 385 nCPM

Immune cell

NK-cell: 4.9 nTPM
memory CD8 T-cell: 3.2 nTPM
naive CD4 T-cell: 3.1 nTPM
naive CD8 T-cell: 3 nTPM
eosinophil: 2.7 nTPM
memory B-cell: 2.4 nTPM

Brain region

cerebellum: 14 nTPM
midbrain: 9.2 nTPM
hypothalamus: 8.9 nTPM
basal ganglia: 8.7 nTPM
choroid plexus: 8.5 nTPM
cerebral cortex: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.04
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Protein kinase domain
Serine/threonine-protein kinase 17A, catalytic domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK17A as an antibody target. Whether an autoantibody or antibody against STK17A could matter depends on whether native STK17A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK17A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK17A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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