Seroatlas · Human Serome Atlas

STK10

Serine/threonine-protein kinase 10

Also known as: LOK, PRO2729, STK10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94804
Gene: STK10
Ensembl: ENSG00000072786
Chromosome: 5
Canonical length: 968 aa
Protein class: Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

968 residues, UniProt reviewed canonical sequence.

>O94804|STK10
     1  MAFANFRRIL RLSTFEKRKS REYEHVRRDL DPNEVWEIVG ELGDGAFGKV YKAKNKETGA
    61  LAAAKVIETK SEEELEDYIV EIEILATCDH PYIVKLLGAY YHDGKLWIMI EFCPGGAVDA
   121  IMLELDRGLT EPQIQVVCRQ MLEALNFLHS KRIIHRDLKA GNVLMTLEGD IRLADFGVSA
   181  KNLKTLQKRD SFIGTPYWMA PEVVMCETMK DTPYDYKADI WSLGITLIEM AQIEPPHHEL
   241  NPMRVLLKIA KSDPPTLLTP SKWSVEFRDF LKIALDKNPE TRPSAAQLLE HPFVSSITSN
   301  KALRELVAEA KAEVMEEIED GRDEGEEEDA VDAASTLENH TQNSSEVSPP SLNADKPLEE
   361  SPSTPLAPSQ SQDSVNEPCS QPSGDRSLQT TSPPVVAPGN ENGLAVPVPL RKSRPVSMDA
   421  RIQVAQEKQV AEQGGDLSPA ANRSQKASQS RPNSSALETL GGEKLANGSL EPPAQAAPGP
   481  SKRDSDCSSL CTSESMDYGT NLSTDLSLNK EMGSLSIKDP KLYKKTLKRT RKFVVDGVEV
   541  SITTSKIISE DEKKDEEMRF LRRQELRELR LLQKEEHRNQ TQLSNKHELQ LEQMHKRFEQ
   601  EINAKKKFFD TELENLERQQ KQQVEKMEQD HAVRRREEAR RIRLEQDRDY TRFQEQLKLM
   661  KKEVKNEVEK LPRQQRKESM KQKMEEHTQK KQLLDRDFVA KQKEDLELAM KRLTTDNRRE
   721  ICDKERECLM KKQELLRDRE AALWEMEEHQ LQERHQLVKQ QLKDQYFLQR HELLRKHEKE
   781  REQMQRYNQR MIEQLKVRQQ QEKARLPKIQ RSEGKTRMAM YKKSLHINGG GSAAEQREKI
   841  KQFSQQEEKR QKSERLQQQQ KHENQMRDML AQCESNMSEL QQLQNEKCHL LVEHETQKLK
   901  ALDESHNQNL KEWRDKLRPR KKALEEDLNQ KKREQEMFFK LSEEAECPNP STPSKAAKFF
   961  PYSSADAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 72 nTPM
spleen: 43 nTPM
lymph node: 41 nTPM
appendix: 35 nTPM
cerebellum: 31 nTPM
tonsil: 24 nTPM

Single-cell type

neutrophils: 1,534 nCPM
monocytes: 649 nCPM
kupffer cells: 494 nCPM
neutrophil progenitors: 459 nCPM
nk-cells: 398 nCPM
t-cells: 277 nCPM

Immune cell

non-classical monocyte: 72 nTPM
neutrophil: 49 nTPM
intermediate monocyte: 46 nTPM
total PBMC: 44 nTPM
gdT-cell: 37 nTPM
MAIT T-cell: 27 nTPM

Brain region

cerebellum: 39 nTPM
white matter: 15 nTPM
thalamus: 15 nTPM
medulla oblongata: 14 nTPM
pons: 13 nTPM
cerebral cortex: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STK10.

Disease | AllUniProt

Conditions STK10 is implicated in, by any mechanism.

Testicular germ cell tumor (TGCT) MIM:273300

Disease | ImmuneIEDB

Conditions an epitope on STK10 was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.47
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Polo kinase kinase
STE20 Subfamily Serine/Threonine Kinases
Protein kinase domain
Polo kinase kinase
Serine/threonine-protein kinase 10, catalytic domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK10 as an antibody target. Whether an autoantibody or antibody against STK10 could matter depends on whether native STK10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK10 is annotated at the cell surface, where native STK10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STK10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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