Seroatlas · Human Serome Atlas

STC2

Stanniocalcin-2

Also known as: STC-2, STC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O76061
Gene
STC2
Ensembl
ENSG00000113739
Chromosome
5
Canonical length
302 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>O76061|STC2
     1  MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA
    61  GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC
   121  ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT
   181  CGEEVKEAIT HSVQVQCEQN WGSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG
   241  EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI
   301  RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
135 nTPM

Expression across tissuesHPA

Tissue

  • breast: 135 nTPM
  • pancreas: 32 nTPM
  • placenta: 26 nTPM
  • smooth muscle: 20 nTPM
  • skin: 15 nTPM
  • spleen: 14 nTPM

Single-cell type

  • breast hormone-responsive cells: 629 nCPM
  • breast myoepithelial cells: 137 nCPM
  • migrating cytotrophoblasts: 92 nCPM
  • extravillous trophoblasts: 71 nCPM
  • breast secretory cells: 40 nCPM
  • cytotrophoblasts: 39 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 12 nTPM
  • medulla oblongata: 9.3 nTPM
  • cerebral cortex: 6.4 nTPM
  • hippocampal formation: 6.3 nTPM
  • pons: 6.2 nTPM
  • thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.27
gnomAD missense Z
1.2
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STC2 as an antibody target. Whether an autoantibody or antibody against STC2 could matter depends on whether native STC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STC2 is annotated as secreted, so native STC2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label STC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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