STATH
Statherin
Also known as: STAT_HUMAN, STR
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P02808
- Gene
- STATH
- Ensembl
- ENSG00000126549
- Chromosome
- 4
- Canonical length
- 62 aa
- Protein class
- Plasma proteins, Predicted secreted proteins, Transporters
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Predicted to enable extracellular matrix constituent, lubricant activity and hydroxyapatite binding activity. Predicted to be a structural constituent of tooth enamel. Predicted to be involved in negative regulation of bone mineralization; ossification; and saliva secretion. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
62 residues, UniProt reviewed canonical sequence.
>P02808|STATH
1 MKFLVFAFIL ALMVSMIGAD SSEEKFLRRI GRFGYGYGPY QPVPEQPLYP QPYQPQYQQY
61 TFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STATH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 8,578 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 8,578 nTPM
- pancreas: 9.3 nTPM
- pituitary gland: 6.5 nTPM
- tongue: 3.1 nTPM
- esophagus: 2.8 nTPM
- heart muscle: 1.7 nTPM
Single-cell type
- salivary acinar cells: 59,340 nCPM
- salivary myoepithelial cells: 15,709 nCPM
- neutrophils: 2,049 nCPM
- submucosal glandular cells: 1,292 nCPM
- salivary basal cells: 610 nCPM
- lacrimal acinar cells: 310 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.31
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- biomineral tissue development
- defense response to bacterium
- negative regulation of bone mineralization
- ossification
- saliva secretion
Molecular functions
- extracellular matrix constituent, lubricant activity
- hydroxyapatite binding
- structural constituent of tooth enamel
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Histatin/statherin family
- Statherin
- Statherin
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STATH as an antibody target. Whether an autoantibody or antibody against STATH could matter depends on whether native STATH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STATH is annotated as secreted, so native STATH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label STATH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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