Seroatlas · Human Serome Atlas

STARD7

StAR-related lipid transfer protein 7, mitochondrial

Also known as: GTT1, STAR7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQZ5
Gene
STARD7
Ensembl
ENSG00000084090
Chromosome
2
Canonical length
370 aa
Protein class
Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

Predicted to enable molecular carrier activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to act upstream of or within several processes, including establishment of skin barrier; mucociliary clearance; and myeloid dendritic cell activation. Located in mitochondrion. Implicated in familial adult myoclonic epilepsy 2. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9NQZ5|STARD7
     1  MLPRRLLAAW LAGTRGGGLL ALLANQCRFV TGLRVRRAQQ IAQLYGRLYS ESSRRVLLGR
    61  LWRRLHGRPG HASALMAALA GVFVWDEERI QEEELQRSIN EMKRLEEMSN MFQSSGVQHH
   121  PPEPKAQTEG NEDSEGKEQR WEMVMDKKHF KLWRRPITGT HLYQYRVFGT YTDVTPRQFF
   181  NVQLDTEYRK KWDALVIKLE VIERDVVSGS EVLHWVTHFP YPMYSRDYVY VRRYSVDQEN
   241  NMMVLVSRAV EHPSVPESPE FVRVRSYESQ MVIRPHKSFD ENGFDYLLTY SDNPQTVFPR
   301  YCVSWMVSSG MPDFLEKLHM ATLKAKNMEI KVKDYISAKP LEMSSEAKAT SQSSERKNEG
   361  SCGPARIEYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
190 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 190 nTPM
  • tongue: 162 nTPM
  • heart muscle: 90 nTPM
  • tonsil: 81 nTPM
  • kidney: 75 nTPM
  • lymph node: 66 nTPM

Single-cell type

  • thymic myoid cells: 222 nCPM
  • kupffer cells: 214 nCPM
  • retinal pigment epithelial cells: 188 nCPM
  • myonuclei: 177 nCPM
  • cardiomyocytes: 167 nCPM
  • hepatocytes: 145 nCPM

Immune cell

  • memory B-cell: 43 nTPM
  • plasmacytoid DC: 42 nTPM
  • T-reg: 42 nTPM
  • naive B-cell: 38 nTPM
  • myeloid DC: 36 nTPM
  • basophil: 36 nTPM

Brain region

  • white matter: 130 nTPM
  • thalamus: 121 nTPM
  • hypothalamus: 109 nTPM
  • cerebellum: 108 nTPM
  • basal ganglia: 107 nTPM
  • choroid plexus: 106 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STARD7.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 69 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Epilepsy, familial adult myoclonic, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.47
gnomAD missense Z
0.96
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STARD7 as an antibody target. Whether an autoantibody or antibody against STARD7 could matter depends on whether native STARD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STARD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STARD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STARD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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