Seroatlas · Human Serome Atlas

STARD6

StAR-related lipid transfer protein 6

Also known as: STAR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59095
Gene: STARD6
Ensembl: ENSG00000174448
Chromosome: 18
Canonical length: 220 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>P59095|STARD6
     1  MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV EGIIPESPAK
    61  LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS FAVGSISPRD FIDLVYIKRY
   121  EGNMNIISSK SVDFPEYPPS SNYIRGYNHP CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS
   181  PSIIEKTMPS NLVNFILNAK DGIKAHRTPS RRGFHHNSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

testis: 1.7 nTPM
spinal cord: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 445 nCPM
late primary spermatocytes: 283 nCPM
early spermatids: 177 nCPM
early primary spermatocytes: 36 nCPM
retinal horizontal cells: 4 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.4 nTPM
cerebral cortex: 0.3 nTPM
pons: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid transport

Molecular functions

lipid binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STARD6 as an antibody target. Whether an autoantibody or antibody against STARD6 could matter depends on whether native STARD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STARD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STARD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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