Seroatlas · Human Serome Atlas

STARD5

StAR-related lipid transfer protein 5

Also known as: MGC10327, STAR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSY2
Gene: STARD5
Ensembl: ENSG00000172345
Chromosome: 15
Canonical length: 213 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9NSY2|STARD5
     1  MDPALAAQMS EAVAEKMLQY RRDTAGWKIC REGNGVSVSW RPSVEFPGNL YRGEGIVYGT
    61  LEEVWDCVKP AVGGLRVKWD ENVTGFEIIQ SITDTLCVSR TSTPSAAMKL ISPRDFVDLV
   121  LVKRYEDGTI SSNATHVEHP LCPPKPGFVR GFNHPCGCFC EPLPGEPTKT NLVTFFHTDL
   181  SGYLPQNVVD SFFPRSMTRF YANLQKAVKQ FHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

skin: 7.4 nTPM
lymph node: 7 nTPM
spleen: 5.7 nTPM
appendix: 5.6 nTPM
cervix: 5.4 nTPM
vagina: 5.3 nTPM

Single-cell type

epicardial cells: 64 nCPM
decidual stromal cells: 50 nCPM
esophageal apical cells: 44 nCPM
plasma cells: 40 nCPM
esophageal suprabasal cells: 32 nCPM
esophageal basal cells: 27 nCPM

Immune cell

basophil: 4.8 nTPM
naive CD8 T-cell: 3.9 nTPM
naive CD4 T-cell: 3.8 nTPM
total PBMC: 3.6 nTPM
T-reg: 3.5 nTPM
memory CD8 T-cell: 3.1 nTPM

Brain region

cerebellum: 6.6 nTPM
white matter: 3.5 nTPM
choroid plexus: 3.4 nTPM
cerebral cortex: 3.1 nTPM
pons: 2.9 nTPM
medulla oblongata: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cholesterol import

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STARD5 as an antibody target. Whether an autoantibody or antibody against STARD5 could matter depends on whether native STARD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STARD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STARD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...