STARD4

Protein identityUniProt · HPA

UniProt accession

Q96DR4

Gene

STARD4

Ensembl

ENSG00000164211

Chromosome

5

Canonical length

205 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q96DR4|STARD4
     1  MEGLSDVASF ATKLKNTLIQ YHSIEEDKWR VAKKTKDVTV WRKPSEEFNG YLYKAQGVID
    61  DLVYSIIDHI RPGPCRLDWD SLMTSLDILE NFEENCCVMR YTTAGQLWNI ISPREFVDFS
   121  YTVGYKEGLL SCGISLDWDE KRPEFVRGYN HPCGWFCVPL KDNPNQSLLT GYIQTDLRGM
   181  IPQSAVDTAM ASTLTNFYGD LRKAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

38 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.82

gnomAD pLI

0

gnomAD missense Z

0.66

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol import
• intracellular cholesterol transport
• positive regulation of bile acid biosynthetic process
• positive regulation of cholesterol metabolic process
• cholesterol transport involved in cholesterol storage

Molecular functions

• cholesterol binding
• cholesterol transfer activity

Cellular components

• cytoplasm
• cytoplasmic vesicle
• cytosol
• endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

• START domain
• START-like domain superfamily
• START domain
• StAR-related lipid transfer protein 4

KeywordsUniProt

• Lipid transport
• Lipid-binding
• Transport