Seroatlas · Human Serome Atlas

STAG3L4

Putative STAG3-like protein 4

Also known as: ST3L4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBR4
Gene: STAG3L4
Canonical length: 150 aa

OverviewNCBI Gene

No narrative summary is available for STAG3L4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q8TBR4|STAG3L4
     1  MSGWIATSKT RMQDFWSLLT FSSDLVDVKD SGDYPLTAPG LSWKKFQGSF CEFVGTLVCR
    61  CQYILLHDDF PMDNLISLLT GFSDSQVCAF CHTSTLAAMK LMTSLVRVAL QLSLHEDINQ
   121  RQYEAERNKG PGQRAPERLE SLLEKHKELH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAG3L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAG3L4 as an antibody target. Whether an autoantibody or antibody against STAG3L4 could matter depends on whether native STAG3L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAG3L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAG3L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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