Seroatlas · Human Serome Atlas

STAG3L3

STAG3-like protein 3

Also known as: ST3L3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CL85
Gene: STAG3L3
Canonical length: 134 aa

OverviewNCBI Gene

No narrative summary is available for STAG3L3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>P0CL85|STAG3L3
     1  MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG WTLHDKHREV
    61  RVKCVKALKG LYGNRDLTAR LELFTGCFKD WMVSMIMDRE YSVAVEAVRL LILILKNMEG
   121  VLMDVDCESV YPIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAG3L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAG3L3 as an antibody target. Whether an autoantibody or antibody against STAG3L3 could matter depends on whether native STAG3L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAG3L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAG3L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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