Seroatlas · Human Serome Atlas

STAG3L1

Putative STAG3-like protein 1

Also known as: ST3L1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CL83
Gene: STAG3L1
Canonical length: 205 aa

OverviewNCBI Gene

No narrative summary is available for STAG3L1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P0CL83|STAG3L1
     1  MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG WTLHDKHREV
    61  RVKCVKALKG LYGNRDLTAR LELFTGRFKD WMVSMIVDRE YSVAVEAVRL LILILKLFYP
   121  ECEIRTMGGR EQRQSPGAQR TFFQLLLSFF VESKLHDHAA YLVDNLWDCA GTQLKDWEGL
   181  TSLLLEKDQS TCHMEPGPGT FHLLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAG3L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAG3L1 as an antibody target. Whether an autoantibody or antibody against STAG3L1 could matter depends on whether native STAG3L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAG3L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAG3L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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