Seroatlas · Human Serome Atlas

ST8SIA6

Alpha-2,8-sialyltransferase 8F

Also known as: SIA8F_HUMAN, SIAT8F

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61647
Gene: ST8SIA6
Ensembl: ENSG00000148488
Chromosome: 10
Canonical length: 398 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>P61647|ST8SIA6
     1  MRPGGALLAL LASLLLLLLL RLLWCPADAP GRARILVEES REATHGTPAA LRTLRSPATA
    61  VPRATNSTYL NEKSLQLTEK CKNLQYGIES FSNKTKGYSE NDYLQIITDI QSCPWKRQAE
   121  EYANFRAKLA SCCDAVQNFV VSQNNTPVGT NMSYEVESKK EIPIKKNIFH MFPVSQPFVD
   181  YPYNQCAVVG NGGILNKSLC GTEIDKSDFV FRCNLPPTTG DVSKDVGSKT NLVTINPSII
   241  TLKYGNLKEK KALFLEDIAT YGDAFFLLPA FSFRANTGTS FKVYYTLEES KARQKVLFFH
   301  PKYLKDLALF WRTKGVTAYR LSTGLMITSV AVELCKNVKL YGFWPFSKTV EDIPVSHHYY
   361  DNKLPKHGFH QMPKEYSQIL QLHMKGILKL QFSKCEVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST8SIA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

lung: 5.6 nTPM
breast: 4.9 nTPM
midbrain: 4.7 nTPM
epididymis: 4.3 nTPM
heart muscle: 3.1 nTPM
bone marrow: 1.6 nTPM

Single-cell type

hematopoietic stem cells: 616 nCPM
megakaryocyte-erythroid progenitors: 601 nCPM
megakaryocyte progenitors: 315 nCPM
melanocytes: 269 nCPM
mast cells: 206 nCPM
respiratory ionocytes: 183 nCPM

Immune cell

basophil: 1.8 nTPM
neutrophil: 1 nTPM
T-reg: 0.8 nTPM
NK-cell: 0.7 nTPM
classical monocyte: 0.5 nTPM
eosinophil: 0.5 nTPM

Brain region

midbrain: 25 nTPM
thalamus: 19 nTPM
amygdala: 14 nTPM
medulla oblongata: 14 nTPM
pons: 12 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST8SIA6 as an antibody target. Whether an autoantibody or antibody against ST8SIA6 could matter depends on whether native ST8SIA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST8SIA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST8SIA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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