Seroatlas · Human Serome Atlas

ST8SIA5

Alpha-2,8-sialyltransferase 8E

Also known as: SIA8E_HUMAN, SIAT8E

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15466
Gene: ST8SIA5
Ensembl: ENSG00000101638
Chromosome: 18
Canonical length: 376 aa
Protein class: Metabolic proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Midbody

OverviewNCBI Gene

The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>O15466|ST8SIA5
     1  MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRYFEFYE GPFEYNSTRC
    61  LELRHEILEV KVLSMVKQSE LFDRWKSLQM CKWAMNISEA NQFKSTLSRC CNAPAFLFTT
   121  QKNTPLGTKL KYEVDTSGIY HINQEIFRMF PKDMPYYRSQ FKKCAVVGNG GILKNSRCGR
   181  EINSADFVFR CNLPPISEKY TMDVGVKTDV VTVNPSIITE RFHKLEKWRR PFYRVLQVYE
   241  NASVLLPAFY NTRNTDVSIR VKYVLDDFES PQAVYYFHPQ YLVNVSRYWL SLGVRAKRIS
   301  TGLILVTAAL ELCEEVHLFG FWAFPMNPSG LYITHHYYDN VKPRPGFHAM PSEIFNFLHL
   361  HSRGILRVHT GTCSCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST8SIA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 23 nTPM
cerebral cortex: 8.9 nTPM
adrenal gland: 5.9 nTPM
parathyroid gland: 5.8 nTPM
hippocampal formation: 4.1 nTPM
amygdala: 2.7 nTPM

Single-cell type

brain excitatory neurons: 133 nCPM
cardiomyocytes: 108 nCPM
adrenal cortex cells: 84 nCPM
brain inhibitory neurons: 77 nCPM
oligodendrocyte progenitor cells: 52 nCPM
retinal amacrine cells: 48 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 56 nTPM
cerebral cortex: 48 nTPM
white matter: 36 nTPM
hippocampal formation: 32 nTPM
basal ganglia: 25 nTPM
amygdala: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ST8SIA5.

Disease | ImmuneIEDB

Conditions an epitope on ST8SIA5 was assayed in.

prostate cancer B cell
glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: 0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST8SIA5 as an antibody target. Whether an autoantibody or antibody against ST8SIA5 could matter depends on whether native ST8SIA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST8SIA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST8SIA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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