Seroatlas · Human Serome Atlas

ST8SIA4

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Also known as: PST, PST1, SIA8D_HUMAN, SIAT8D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92187
Gene: ST8SIA4
Ensembl: ENSG00000113532
Chromosome: 5
Canonical length: 359 aa
Protein class: Metabolic proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted - unknown location

OverviewNCBI Gene

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q92187|ST8SIA4
     1  MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELSLSRSLVN SSDKIIRKAG
    61  SSIFQHNVEG WKINSSLVLE IRKNILRFLD AERDVSVVKS SFKPGDVIHY VLDRRRTLNI
   121  SHDLHSLLPE VSPMKNRRFK TCAVVGNSGI LLDSECGKEI DSHNFVIRCN LAPVVEFAAD
   181  VGTKSDFITM NPSVVQRAFG GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV
   241  NALILKNKLK VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF
   301  WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK LTTGKCVKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST8SIA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

appendix: 13 nTPM
lymph node: 12 nTPM
spleen: 11 nTPM
placenta: 11 nTPM
tonsil: 9.7 nTPM
thymus: 8.8 nTPM

Single-cell type

neutrophils: 718 nCPM
cdc: 357 nCPM
microglia: 304 nCPM
monocytes: 263 nCPM
kupffer cells: 240 nCPM
neutrophil progenitors: 204 nCPM

Immune cell

neutrophil: 92 nTPM
basophil: 58 nTPM
non-classical monocyte: 24 nTPM
eosinophil: 23 nTPM
intermediate monocyte: 22 nTPM
classical monocyte: 19 nTPM

Brain region

pons: 13 nTPM
white matter: 12 nTPM
hypothalamus: 12 nTPM
thalamus: 10 nTPM
medulla oblongata: 9.8 nTPM
midbrain: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.74
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST8SIA4 as an antibody target. Whether an autoantibody or antibody against ST8SIA4 could matter depends on whether native ST8SIA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST8SIA4 is annotated as secreted, so native ST8SIA4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ST8SIA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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