Seroatlas · Human Serome Atlas

ST8SIA2

Alpha-2,8-sialyltransferase 8B

Also known as: HsT19690, SIA8B_HUMAN, SIAT8B, ST8SIA-II, STX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92186
Gene: ST8SIA2
Ensembl: ENSG00000140557
Chromosome: 15
Canonical length: 375 aa
Protein class: Predicted secreted proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q92186|ST8SIA2
     1  MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS KSNRAEVVIN
    61  GSSSPAVVDR SNESIKHNIQ PASSKWRHNQ TLSLRIRKQI LKFLDAEKDI SVLKGTLKPG
   121  DIIHYIFDRD STMNVSQNLY ELLPRTSPLK NKHFGTCAIV GNSGVLLNSG CGQEIDAHSF
   181  VIRCNLAPVQ EYARDVGLKT DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HSLNGSILWI
   241  PAFMARGGKE RVEWVNELIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY
   301  TLATRFCKQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL EFKALKSLHE
   361  QGALKLTVGQ CDGAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST8SIA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 3.6 nTPM
thymus: 1.7 nTPM
cerebral cortex: 1.1 nTPM
hypothalamus: 1.1 nTPM
hippocampal formation: 0.9 nTPM
cervix: 0.8 nTPM

Single-cell type

retinal amacrine cells: 9.9 nCPM
other brain neurons: 9.3 nCPM
brain excitatory neurons: 9.1 nCPM
brain inhibitory neurons: 6.5 nCPM
pituitary stem cells: 6.4 nCPM
müller glia: 5.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 19 nTPM
medulla oblongata: 8.7 nTPM
cerebral cortex: 7 nTPM
midbrain: 4.4 nTPM
hippocampal formation: 3.6 nTPM
hypothalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.06
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST8SIA2 as an antibody target. Whether an autoantibody or antibody against ST8SIA2 could matter depends on whether native ST8SIA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST8SIA2 is annotated at the cell surface, where native ST8SIA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ST8SIA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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