Seroatlas · Human Serome Atlas

ST7L

Suppressor of tumorigenicity 7 protein-like

Also known as: FAM4B, FLJ20284, ST7L_HUMAN, ST7R, STLR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDW4
Gene: ST7L
Ensembl: ENSG00000007341
Chromosome: 1
Canonical length: 575 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q8TDW4|ST7L
     1  MADRGGVGEA AAVGASPASV PGLNPTLGWR ERLRAGLAGT GASLWFVAGL GLLYALRIPL
    61  RLCENLAAVT VFLNSLTPKF YVALTGTSSL ISGLIFIFEW WYFHKHGTSF IEQVSVSHLQ
   121  PLMGGTESSI SEPGSPSRNR ENETSRQNLS ECKVWRNPLN LFRGAEYRRY TWVTGKEPLT
   181  YYDMNLSAQD HQTFFTCDTD FLRPSDTVMQ KAWRERNPPA RIKAAYQALE LNNDCATAYV
   241  LLAEEEATTI VDAERLFKQA LKAGETIYRQ SQQCQHQSPQ HEAQLRRDTN VLVYIKRRLA
   301  MCARKLGRIR EAVKIMRDLM KEFPPLTMLN IHENLLESLL ELQAYPDVQA VLAKYDDISL
   361  PKSAAICYTA ALLKTRTVSE KFSPETASRR GLSTAEINAV EAIHRAVEFN PHVPKYLLEM
   421  KSLILPPEHI LKRGDSEAIA YAFFHLQHWK RIEGALNLLQ CTWEGTFRMI PYPLEKGHLF
   481  YPYPSCTETA DRELLPTFHH VSVYPKKELP LFIHFTAGFC SSTAMIAILT HQFPEIMGIF
   541  AKAVLGLWCP QPWASSGFEE NTQDLKSEDL GLSSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
thyroid gland: 7.1 nTPM
retina: 6.3 nTPM
skin: 5.8 nTPM
bone marrow: 5.2 nTPM
heart muscle: 5.1 nTPM

Single-cell type

late spermatids: 530 nCPM
early spermatids: 223 nCPM
late primary spermatocytes: 219 nCPM
cardiomyocytes: 175 nCPM
myonuclei: 158 nCPM
choroid plexus epithelial cells: 110 nCPM

Immune cell

NK-cell: 3.8 nTPM
naive CD4 T-cell: 2.5 nTPM
memory B-cell: 2.4 nTPM
MAIT T-cell: 1.9 nTPM
memory CD4 T-cell: 1.8 nTPM
plasmacytoid DC: 1.8 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 11 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 10 nTPM
choroid plexus: 9.2 nTPM
amygdala: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of cell growth

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST7L as an antibody target. Whether an autoantibody or antibody against ST7L could matter depends on whether native ST7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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