Seroatlas · Human Serome Atlas

ST6GALNAC6

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Also known as: SIA7F_HUMAN, SIAT7F, ST6GALNACVI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969X2
Gene: ST6GALNAC6
Ensembl: ENSG00000160408
Chromosome: 9
Canonical length: 333 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q969X2|ST6GALNAC6
     1  MACSRPPSQC EPTSLPPGPP AGRRHLPLSR RRREMSSNKE QRSAVFVILF ALITILILYS
    61  SNSANEVFHY GSLRGRSRRP VNLKKWSITD GYVPILGNKT LPSRCHQCVI VSSSSHLLGT
   121  KLGPEIERAE CTIRMNDAPT TGYSADVGNK TTYRVVAHSS VFRVLRRPQE FVNRTPETVF
   181  IFWGPPSKMQ KPQGSLVRVI QRAGLVFPNM EAYAVSPGRM RQFDDLFRGE TGKDREKSHS
   241  WLSTGWFTMV IAVELCDHVH VYGMVPPNYC SQRPRLQRMP YHYYEPKGPD ECVTYIQNEH
   301  SRKGNHHRFI TEKRVFSSWA QLYGITFSHP SWT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST6GALNAC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

amygdala: 181 nTPM
cerebral cortex: 175 nTPM
hippocampal formation: 163 nTPM
basal ganglia: 153 nTPM
rectum: 119 nTPM
blood vessel: 116 nTPM

Single-cell type

ependymal cells: 16 nCPM
bergmann glia: 15 nCPM
brain excitatory neurons: 14 nCPM
astrocytes: 12 nCPM
brain inhibitory neurons: 11 nCPM
other brain neurons: 11 nCPM

Immune cell

T-reg: 26 nTPM
gdT-cell: 25 nTPM
NK-cell: 24 nTPM
memory CD8 T-cell: 19 nTPM
MAIT T-cell: 19 nTPM
memory CD4 T-cell: 17 nTPM

Brain region

hippocampal formation: 135 nTPM
cerebral cortex: 113 nTPM
basal ganglia: 113 nTPM
amygdala: 113 nTPM
thalamus: 83 nTPM
midbrain: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 1.57
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST6GALNAC6 as an antibody target. Whether an autoantibody or antibody against ST6GALNAC6 could matter depends on whether native ST6GALNAC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST6GALNAC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST6GALNAC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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