ST6GALNAC5
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Also known as: MGC3184, SIA7E_HUMAN, SIAT7E, ST6GalNAcV
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BVH7
- Gene
- ST6GALNAC5
- Ensembl
- ENSG00000117069
- Chromosome
- 1
- Canonical length
- 336 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Vesicles
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Canonical amino-acid sequenceUniProt
336 residues, UniProt reviewed canonical sequence.
>Q9BVH7|ST6GALNAC5
1 MKTLMRHGLA VCLALTTMCT SLLLVYSSLG GQKERPPQQQ QQQQQQQQQA SATGSSQPAA
61 ESSTQQRPGV PAGPRPLDGY LGVADHKPLK MHCRDCALVT SSGHLLHSRQ GSQIDQTECV
121 IRMNDAPTRG YGRDVGNRTS LRVIAHSSIQ RILRNRHDLL NVSQGTVFIF WGPSSYMRRD
181 GKGQVYNNLH LLSQVLPRLK AFMITRHKML QFDELFKQET GKDRKISNTW LSTGWFTMTI
241 ALELCDRINV YGMVPPDFCR DPNHPSVPYH YYEPFGPDEC TMYLSHERGR KGSHHRFITE
301 KRVFKNWART FNIHFFQPDW KPESLAINHP ENKPVFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ST6GALNAC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 3.5 nTPM
Expression across tissuesHPA
Tissue
- hippocampal formation: 3.5 nTPM
- lung: 3.4 nTPM
- blood vessel: 3.3 nTPM
- cerebral cortex: 3.2 nTPM
- retina: 3 nTPM
- adrenal gland: 2.8 nTPM
Single-cell type
- thyrotrophs: 846 nCPM
- brain excitatory neurons: 702 nCPM
- corticotrophs: 541 nCPM
- pituitary stem cells: 532 nCPM
- lactotrophs: 525 nCPM
- retinal bipolar cells: 465 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 18 nTPM
- hippocampal formation: 16 nTPM
- amygdala: 7.3 nTPM
- basal ganglia: 6.8 nTPM
- white matter: 4.5 nTPM
- midbrain: 3.3 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ST6GALNAC5.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 62 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.61
- gnomAD pLI
- 0.17
- gnomAD missense Z
- 0.54
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- ganglioside biosynthetic process
- glycosphingolipid biosynthetic process
- oligosaccharide biosynthetic process
- oligosaccharide metabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ST6GALNAC5 as an antibody target. Whether an autoantibody or antibody against ST6GALNAC5 could matter depends on whether native ST6GALNAC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ST6GALNAC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ST6GALNAC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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