Seroatlas · Human Serome Atlas

ST6GALNAC3

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Also known as: SIA7C_HUMAN, SIAT7C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDV1
Gene: ST6GALNAC3
Ensembl: ENSG00000184005
Chromosome: 1
Canonical length: 305 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q8NDV1|ST6GALNAC3
     1  MACILKRKSV IAVSFIAAFL FLLVVRLVNE VNFPLLLNCF GQPGTKWIPF SYTYRRPLRT
    61  HYGYINVKTQ EPLQLDCDLC AIVSNSGQMV GQKVGNEIDR SSCIWRMNNA PTKGYEEDVG
   121  RMTMIRVVSH TSVPLLLKNP DYFFKEANTT IYVIWGPFRN MRKDGNGIVY NMLKKTVGIY
   181  PNAQIYVTTE KRMSYCDGVF KKETGKDRVQ SGSYLSTGWF TFLLAMDACY GIHVYGMIND
   241  TYCKTEGYRK VPYHYYEQGR DECDEYFLHE HAPYGGHRFI TEKKVFAKWA KKHRIIFTHP
   301  NWTLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST6GALNAC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 13 nTPM
spinal cord: 9.6 nTPM
kidney: 8.1 nTPM
adipose tissue: 7.5 nTPM
choroid plexus: 6.2 nTPM
tongue: 6.1 nTPM

Single-cell type

podocytes: 8,623 nCPM
neutrophils: 3,520 nCPM
microglia: 2,471 nCPM
choroid plexus epithelial cells: 1,708 nCPM
neutrophil progenitors: 1,413 nCPM
lymphatic endothelial cells: 1,236 nCPM

Immune cell

classical monocyte: 6.3 nTPM
non-classical monocyte: 4.4 nTPM
neutrophil: 3.9 nTPM
naive B-cell: 3.8 nTPM
eosinophil: 2.8 nTPM
memory B-cell: 2.6 nTPM

Brain region

white matter: 48 nTPM
medulla oblongata: 42 nTPM
cerebellum: 36 nTPM
pons: 36 nTPM
spinal cord: 34 nTPM
basal ganglia: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ST6GALNAC3.

Disease | ImmuneIEDB

Conditions an epitope on ST6GALNAC3 was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST6GALNAC3 as an antibody target. Whether an autoantibody or antibody against ST6GALNAC3 could matter depends on whether native ST6GALNAC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST6GALNAC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST6GALNAC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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