Seroatlas · Human Serome Atlas

ST6GALNAC2

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Also known as: SIA7B_HUMAN, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJ37
Gene: ST6GALNAC2
Ensembl: ENSG00000070731
Chromosome: 17
Canonical length: 374 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q9UJ37|ST6GALNAC2
     1  MGLPRGSFFW LLLLLTAACS GLLFALYFSA VQRYPGPAAG ARDTTSFEAF FQSKASNSWT
    61  GKGQACRHLL HLAIQRHPHF RGLFNLSIPV LLWGDLFTPA LWDRLSQHKA PYGWRGLSHQ
   121  VIASTLSLLN GSESAKLFAP PRDTPPKCIR CAVVGNGGIL NGSRQGPNID AHDYVFRLNG
   181  AVIKGFERDV GTKTSFYGFT VNTMKNSLVS YWNLGFTSVP QGQDLQYIFI PSDIRDYVML
   241  RSAILGVPVP EGLDKGDRPH AYFGPEASAS KFKLLHPDFI SYLTERFLKS KLINTHFGDL
   301  YMPSTGALML LTALHTCDQV SAYGFITSNY WKFSDHYFER KMKPLIFYAN HDLSLEAALW
   361  RDLHKAGILQ LYQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST6GALNAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 123 nTPM
retina: 49 nTPM
skin: 49 nTPM
fallopian tube: 48 nTPM
testis: 41 nTPM
thyroid gland: 24 nTPM

Single-cell type

rod photoreceptor cells: 207 nCPM
neutrophils: 115 nCPM
schwann cells: 101 nCPM
retinal pigment epithelial cells: 90 nCPM
respiratory ciliated cells: 85 nCPM
müller glia: 76 nCPM

Immune cell

neutrophil: 47 nTPM
eosinophil: 5.2 nTPM
classical monocyte: 3 nTPM
intermediate monocyte: 1.8 nTPM
myeloid DC: 0.4 nTPM
non-classical monocyte: 0.4 nTPM

Brain region

choroid plexus: 70 nTPM
midbrain: 13 nTPM
medulla oblongata: 11 nTPM
spinal cord: 7.7 nTPM
white matter: 4.7 nTPM
thalamus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST6GALNAC2 as an antibody target. Whether an autoantibody or antibody against ST6GALNAC2 could matter depends on whether native ST6GALNAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST6GALNAC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST6GALNAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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