Seroatlas · Human Serome Atlas

ST6GALNAC1

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Also known as: SIA7A_HUMAN, SIAT7A, ST6GalNAcI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSC7
Gene
ST6GALNAC1
Ensembl
ENSG00000070526
Chromosome
17
Canonical length
600 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>Q9NSC7|ST6GALNAC1
     1  MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN IKERSLQSLA
    61  KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR GKEANQAPPE EQDKVPHTAQ
   121  RAAWKSPEKE KTMVNTLSPR GQDAGMASGR TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV
   181  SEKHQGKAAT TAKTLIPKSQ HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF
   241  QSPTTQRNQR LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN
   301  LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL LLASLPAGSL
   361  RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY EQDVGTRTSF YGFTAFSLTQ
   421  SLLILGNRGF KNVPLGKDVR YLHFLEGTRD YEWLEALLMN QTVMSKNLFW FRHRPQEAFR
   481  EALHMDRYLL LHPDFLRYMK NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG
   541  FITEGHERFS DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST6GALNAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
184 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 184 nTPM
  • colon: 146 nTPM
  • small intestine: 71 nTPM
  • stomach: 61 nTPM
  • duodenum: 59 nTPM
  • cervix: 58 nTPM

Single-cell type

  • goblet cells: 811 nCPM
  • esophageal apical cells: 310 nCPM
  • respiratory secretory cells: 232 nCPM
  • parietal cells: 225 nCPM
  • respiratory basal cells: 143 nCPM
  • respiratory deuterosomal cells: 134 nCPM

Immune cell

  • memory CD4 T-cell: 8.9 nTPM
  • naive CD4 T-cell: 3.4 nTPM
  • T-reg: 1.3 nTPM
  • total PBMC: 0.9 nTPM
  • gdT-cell: 0.2 nTPM
  • neutrophil: 0.2 nTPM

Brain region

  • pons: 4.4 nTPM
  • thalamus: 3.9 nTPM
  • medulla oblongata: 3.6 nTPM
  • amygdala: 3.4 nTPM
  • cerebral cortex: 3.4 nTPM
  • hypothalamus: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.14
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST6GALNAC1 as an antibody target. Whether an autoantibody or antibody against ST6GALNAC1 could matter depends on whether native ST6GALNAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST6GALNAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST6GALNAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ST6GALNAC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...