Seroatlas · Human Serome Atlas

ST3GAL6

Type 2 lactosamine alpha-2,3-sialyltransferase

Also known as: SIA10_HUMAN, SIAT10, ST3GALVI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y274
Gene
ST3GAL6
Ensembl
ENSG00000064225
Chromosome
3
Canonical length
331 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q9Y274|ST3GAL6
     1  MRGYLVAIFL SAVFLYYVLH CILWGTNVYW VAPVEMKRRN KIQPCLSKPA FASLLRFHQF
    61  HPFLCAADFR KIASLYGSDK FDLPYGMRTS AEYFRLALSK LQSCDLFDEF DNIPCKKCVV
   121  VGNGGVLKNK TLGEKIDSYD VIIRMNNGPV LGHEEEVGRR TTFRLFYPES VFSDPIHNDP
   181  NTTVILTAFK PHDLRWLLEL LMGDKINTNG FWKKPALNLI YKPYQIRILD PFIIRTAAYE
   241  LLHFPKVFPK NQKPKHPTTG IIAITLAFYI CHEVHLAGFK YNFSDLKSPL HYYGNATMSL
   301  MNKNAYHNVT AEQLFLKDII EKNLVINLTQ D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST3GAL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • liver: 39 nTPM
  • heart muscle: 21 nTPM
  • salivary gland: 12 nTPM
  • adipose tissue: 11 nTPM
  • kidney: 10 nTPM
  • skin: 8.6 nTPM

Single-cell type

  • podocytes: 1,444 nCPM
  • bergmann glia: 722 nCPM
  • cardiomyocytes: 556 nCPM
  • melanocytes: 428 nCPM
  • salivary acinar cells: 391 nCPM
  • microglia: 280 nCPM

Immune cell

  • neutrophil: 51 nTPM
  • eosinophil: 41 nTPM
  • myeloid DC: 20 nTPM
  • basophil: 19 nTPM
  • classical monocyte: 15 nTPM
  • intermediate monocyte: 8.2 nTPM

Brain region

  • medulla oblongata: 25 nTPM
  • spinal cord: 21 nTPM
  • cerebellum: 19 nTPM
  • white matter: 18 nTPM
  • pons: 17 nTPM
  • cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.91
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST3GAL6 as an antibody target. Whether an autoantibody or antibody against ST3GAL6 could matter depends on whether native ST3GAL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST3GAL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST3GAL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ST3GAL6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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