Seroatlas · Human Serome Atlas

ST3GAL4

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Also known as: CGS23, FLJ11867, NANTA3, SAT3, SIA4C_HUMAN, SIAT4, SIAT4C, STZ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q11206
Gene
ST3GAL4
Ensembl
ENSG00000110080
Chromosome
11
Canonical length
333 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q11206|ST3GAL4
     1  MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE AESKASKLFG
    61  NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV LAITSSSIPK NIQSLRCRRC
   121  VVVGNGHRLR NSSLGDAINK YDVVIRLNNA PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE
   181  NNPDTLLVLV AFKAMDFHWI ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA
   241  ADKLLSLPMQ QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
   301  LKSMAGSGHN VSQEALAIKR MLEMGAIKNL TSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST3GAL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 110 nTPM
  • ovary: 107 nTPM
  • epididymis: 83 nTPM
  • esophagus: 66 nTPM
  • spinal cord: 63 nTPM
  • rectum: 62 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,342 nCPM
  • esophageal apical cells: 1,314 nCPM
  • neutrophils: 266 nCPM
  • melanocytes: 262 nCPM
  • epididymal principal cells: 209 nCPM
  • retinal pigment epithelial cells: 192 nCPM

Immune cell

  • basophil: 112 nTPM
  • plasmacytoid DC: 94 nTPM
  • neutrophil: 72 nTPM
  • myeloid DC: 21 nTPM
  • intermediate monocyte: 8.7 nTPM
  • total PBMC: 6.4 nTPM

Brain region

  • white matter: 92 nTPM
  • cerebellum: 67 nTPM
  • medulla oblongata: 65 nTPM
  • midbrain: 62 nTPM
  • basal ganglia: 61 nTPM
  • pons: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.04
gnomAD missense Z
1.58
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST3GAL4 as an antibody target. Whether an autoantibody or antibody against ST3GAL4 could matter depends on whether native ST3GAL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST3GAL4 is annotated as secreted, so native ST3GAL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ST3GAL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ST3GAL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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