Seroatlas · Human Serome Atlas

ST3GAL2

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

Also known as: SIA4B_HUMAN, SIAT4B, ST3GalA.2, ST3GALII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16842
Gene: ST3GAL2
Ensembl: ENSG00000157350
Chromosome: 16
Canonical length: 350 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q16842|ST3GAL2
     1  MKCSLRVWFL SVAFLLVFIM SLLFTYSHHS MATLPYLDSG ALDGTHRVKL VPGYAGLQRL
    61  SKERLSGKSC ACRRCMGDAG ASDWFDSHFD GNISPVWTRE NMDLPPDVQR WWMMLQPQFK
   121  SHNTNEVLEK LFQIVPGENP YRFRDPHQCR RCAVVGNSGN LRGSGYGQDV DGHNFIMRMN
   181  QAPTVGFEQD VGSRTTHHFM YPESAKNLPA NVSFVLVPFK VLDLLWIASA LSTGQIRFTY
   241  APVKSFLRVD KEKVQIYNPA FFKYIHDRWT EHHGRYPSTG MLVLFFALHV CDEVNVYGFG
   301  ADSRGNWHHY WENNRYAGEF RKTGVHDADF EAHIIDMLAK ASKIEVYRGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST3GAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
cerebellum: 11 nTPM
spleen: 7.8 nTPM
endometrium: 7 nTPM
bone marrow: 6.9 nTPM
basal ganglia: 6.7 nTPM

Single-cell type

neutrophils: 372 nCPM
pdcs: 174 nCPM
erythrocyte progenitors: 95 nCPM
cdc: 87 nCPM
neutrophil progenitors: 83 nCPM
gonadotrophs: 79 nCPM

Immune cell

plasmacytoid DC: 14 nTPM
neutrophil: 9.9 nTPM
eosinophil: 5.2 nTPM
basophil: 4 nTPM
naive CD4 T-cell: 3.8 nTPM
naive CD8 T-cell: 3 nTPM

Brain region

cerebellum: 24 nTPM
hippocampal formation: 22 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 19 nTPM
amygdala: 17 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 1.7
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST3GAL2 as an antibody target. Whether an autoantibody or antibody against ST3GAL2 could matter depends on whether native ST3GAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST3GAL2 is annotated as secreted, so native ST3GAL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ST3GAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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