Seroatlas · Human Serome Atlas

ST20

Suppressor of tumorigenicity 20 protein

Also known as: ST20_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBF5
Gene: ST20
Canonical length: 79 aa

OverviewNCBI Gene

No narrative summary is available for ST20 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>Q9HBF5|ST20
     1  MARSRLTATS VSQVQENGFV KKLEPKSGWM TFLEVTGKIC EMLFCPEAIL LTRKDTPYCE
    61  TGLIFLTLTK TIANTYFYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.37
gnomAD missense Z: 0.04

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type endopeptidase activator activity

KeywordsUniProt

Tumor suppressor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST20 as an antibody target. Whether an autoantibody or antibody against ST20 could matter depends on whether native ST20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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